TLDR Inositol and arginine solutions improve hair follicle health and turnover.
The study aimed to evaluate the biological activity of anisotropic osmolyte solutions (Inositol + Arginine) on the hair follicle (HF) cycle, focusing on the interaction between dermal papilla fibroblast (DPF) and keratinocytes of the outer root sheath (ORSK). The researchers utilized a 3D micro-hair follicle (µHF) model created using hanging drop technology for a DPF-ORSK co-culture, which allowed for a more accurate representation of cell distribution and interaction. This model demonstrated the ability to assess the effectiveness of the osmolyte solutions in improving follicle turnover and health. Additionally, an in silico model was employed to identify the most promising osmolyte combinations, and the findings were validated through in vivo evaluations on volunteers with hair disorders.
256 citations,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Growing human skin cells in a 3D environment can stimulate new hair growth.
417 citations,
September 2005 in “PLoS biology” Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
51 citations,
January 2004 in “Skin Pharmacology and Physiology” The document explains hair growth and shedding, factors affecting it, and methods to evaluate hair loss, emphasizing the importance of skin biopsy for diagnosis.
1113 citations,
August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
745 citations,
February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
17 citations,
February 2015 in “International Journal of Molecular Sciences” A special mix from certain skin cells can help hair grow by making hair root cells grow faster and activating growth signals.
152 citations,
December 2003 in “Micron” As people age, their hair follicles produce less pigment, leading to gray and white hair, due to factors like reduced enzyme activity and damage to melanocyte DNA.
130 citations,
December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair follicle melanocytes die during hair regression.
