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research In-Silico Modelling of Transdermal Delivery of Macromolecule Drugs Assisted by a Skin Stretching Hypobaric Device

1 citations , November 2022 in “Pharmaceutical research”

In this study, the authors found that applying hypobaric pressure to the skin significantly increases the transdermal permeation of large molecules by enhancing diffusion, despite the associated skin stretching and hair follicle enlargement not fully explaining this effect.

research In-silico cardiac aging regulatory model including microRNA post-transcriptional regulation

3 citations , June 2017 in “Methods”

This study used computational modeling to identify key genes and miRs involved in cardiac aging, finding a strong relationship supported by literature and some experimental validation in aged mouse hearts.

research The impact of skin massage frequency on the intrafollicular transport of silica nanoparticles: Validation of the ratchet effect on an ex vivo porcine skin model

21 citations , November 2020 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study found that low massage frequencies like 4.2 Hz enhance nanoparticle penetration into hair follicles more effectively than higher frequencies, indicating potential applications in therapeutic and cosmetic delivery.

research PVA based nanofiber containing CQDs modified with silica NPs and silk fibroin accelerates wound healing in a rat model

87 citations , December 2020 in “Journal of Materials Chemistry B”

This study found that a nanofiber wound dressing made of CQD/Si NP/SF significantly inhibits bacterial growth and accelerates skin wound healing and hair follicle regeneration in animal models.

research Experimental Assessment of 3-meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-α-Reductase Inhibitors in silico</i> and in vivo* Models*

January 2023 in “Bioorganičeskaâ himiâ”

This study found that a new deoxycholic acid derivative may offer a similar prostatoprotective effect to finasteride with lower toxicity in rat models.

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Community Join

5 / 55 results

community Re:you (NOVOGRO) New Hair Loss Treatment Coming in August

45 upvotes 3 months ago

NOVOGRO's new hair loss treatment is questioned for its effectiveness compared to minoxidil, with skepticism about its claims and trial results. The product targets women and lacks the 5α-reductase inhibitor NV-1065, which is still in development.

community Youre missing something in your battle against hairloss.

33 upvotes 1 year ago

Moringa extract and oil are suggested to help with hair loss, with some users combining it with treatments like minoxidil, finasteride, and dutasteride. Moringa is claimed to improve hair growth and health, but evidence is mostly anecdotal.

community Does anyone know the chemical formula for pelage pp405?

15 upvotes 1 year ago

The conversation discusses the lack of public information on the chemical structure of PP405, a hair loss treatment, and the challenges of synthesizing it without a patent. It also explores a patent related to hydrogen-based topical formulations for reducing oxidative stress and inflammation.

community early 20s, hair thinning, looking for natural remedies not expensive soaps

in Female 3 months ago

The user is experiencing hair thinning and prefers natural remedies over expensive shampoos. Other users suggest that natural remedies are ineffective and recommend medications like minoxidil and finasteride, while also considering diet and lifestyle changes.

community Soo.. uhh.. one year... wondering when Dutasteride is going to stop hair loss

131 upvotes 3 years ago

User has been on finasteride and switched to Dutasteride 6 months ago, using minoxidil, tretinoin, microneedling, and RU-58841, but still experiencing hair loss. Advice given includes waiting 6-18 months for Dutasteride results and checking if it's definitely MPB.

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Learn

2 / 2 results

learn Silica

learn horsetail extract

How does horsetail extract support hair growth — is it the silica, the antioxidants, or both? No trial has tested horsetail alone for hair. Its silica and antioxidant content are proposed mechanisms, not proven effects.

Clinics

3 / 3 results

Experts

3 / 6 results