The Impact of Skin Massage Frequency on the Intrafollicular Transport of Silica Nanoparticles: Validation of the Ratchet Effect on an Ex Vivo Porcine Skin Model

November 2020 in “ European Journal of Pharmaceutics and Biopharmaceutics ”

Loris Busch, Yasemin Keziban, Lars Dähne, Cornelia M. Keck, Martina C. Meinke, Jürgen Lademann, Alexa Patzelt

silica nanoparticles Cy5-SNPs hair follicles ex vivo porcine skin model massage frequency follicular penetration nanoparticles

Studysummary This study found that low massage frequencies like 4.2 Hz enhance nanoparticle penetration into hair follicles more effectively than higher frequencies, indicating potential applications in therapeutic and cosmetic delivery.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

18 / 18 results

research Dutasteride Nanocapsules for Hair Follicle Targeting: Effect of Chitosan-Coating and Physical Stimulus

26 citations , February 2020 in “International Journal of Biological Macromolecules”

This study demonstrates that massage significantly enhances the follicular targeting of dutasteride-loaded nanocapsules, increasing drug accumulation in hair follicles by up to 5 times.

research Effect of Physical Stimuli on Hair Follicle Deposition of Clobetasol-Loaded Lipid Nanocarriers

52 citations , January 2020 in “Scientific Reports”

This study found that nanostructured lipid carriers with clobetasol propionate significantly enhance follicular drug delivery compared to commercial cream, and manual massage further doubles follicular retention.

research Increasing the Percutaneous Absorption and Follicular Penetration of Retinal by Topical Application of Proretinal Nanoparticles

14 citations , March 2019 in “European journal of pharmaceutics and biopharmaceutics”

This study observed that proretinal nanoparticles delivered significantly higher concentrations of retinal to the stratum corneum and hair follicles compared to non-particulate forms, potentially improving topical retinoid therapy.

Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

research Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

17 citations , June 2017 in “Journal of pharmaceutical sciences”

This study found that adapalene-loaded nanospheres in a hyaluronic acid gel enhanced skin penetration and were nonirritant, making them potentially suitable for treating acne on oily skin.

Nanocarriers for Optimizing the Balance Between Interfollicular Permeation and Follicular Uptake of Topically Applied Clobetasol to Minimize Adverse Effects

research Nanocarriers for Optimizing the Balance Between Interfollicular Permeation and Follicular Uptake of Topically Applied Clobetasol to Minimize Adverse Effects

69 citations , December 2015 in “Journal of Controlled Release”

This study found that nanocapsules formulated as a dispersion and applied with massage may enhance follicular uptake of clobetasol propionate while minimizing its skin penetration, offering a potential improvement over conventional treatments for scalp diseases.

research Significance of the Follicular Pathway for Dermal Substance Penetration Quantified by Laser Doppler Flowmetry

10 citations , August 2015 in “Journal of biophotonics”

This study found that applying benzyl nicotinate on open hair follicles led to a significant increase in blood flow, highlighting the role of the follicular pathway in epidermal penetration.

research Inverse Micellar Sugar Glass (IMSG) Nanoparticles for Transfollicular Vaccination

38 citations , March 2015 in “Journal of controlled release”

This study found that transfollicular delivery using surfactant-based nanoparticles significantly enhanced antigen stability and immune response compared to other delivery methods, especially when combined with an adjuvant.

research Influence of Massage and Occlusion on the Ex Vivo Skin Penetration of Rigid Liposomes and Invasomes

39 citations , November 2013 in “European journal of pharmaceutics and biopharmaceutics”

This study found that massaging the skin significantly increases follicular penetration of liposomes in an ex vivo setting, while occlusion only enhanced penetration for rigid liposomes.

research Drug Delivery to Hair Follicles

122 citations , March 2013 in “Expert opinion on drug delivery”

This review summarizes drug delivery strategies to hair follicles, highlighting physicochemical factors affecting penetration and the use of stimuli-responsive particulate carriers, but reports no new clinical findings.

research In Vivo Investigation of the Efficiency of a Nanoparticle-Emulsion Containing Polihexanide on Human Skin

21 citations , December 2012 in “European journal of pharmaceutics and biopharmaceutics”

This study suggests that using particle-bound antiseptics may provide more effective and longer-lasting skin antisepsis compared to their non-particulate forms.

research Nanoparticles Enhance Therapeutic Outcome in Inflamed Skin Therapy

80 citations , June 2012 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study observed that smaller polymeric submicron particles provided more efficient selective drug delivery to inflamed skin in a mouse model, enhancing therapeutic effects while reducing systemic adverse effects.

research Selective Follicular Targeting by Modification of the Particle Sizes

263 citations , February 2011 in “Journal of Controlled Release”

This study found that medium-sized particles (643 and 646 nm) penetrated deeper into porcine hair follicles in vitro than smaller or larger particles, suggesting size-selective targeting within follicular sites.

research Determination of the Cuticle Thickness of Human and Porcine Hairs and Their Potential Influence on the Penetration of Nanoparticles into the Hair Follicles

95 citations , January 2009 in “Journal of Biomedical Optics”

This study observed that particles sized 300-600 nm penetrate hair follicles more efficiently, likely due to alignment with the thickness of the human hair cuticula.

research Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation

93 citations , January 2007 in “Skin Pharmacology and Physiology”

In this study, caffeine applied in a shampoo penetrated hair follicles faster and more effectively than through the skin surface within the first 20 minutes.

research 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin

323 citations , April 2006 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that 40 nm nanoparticles can effectively penetrate into hair follicles and epidermal Langerhans cells in human skin samples, potentially enabling efficient transcutaneous vaccine delivery.

research Gene Delivery to the Hair Follicle

34 citations , September 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses advancements in gene delivery to hair follicles and suggests potential gene therapy applications for treating hair loss, but it reports no new experimental results.

research Importance of Sebaceous Glands in Cutaneous Penetration of an Antiandrogen: Target Effect of Liposomes

62 citations , May 1997 in “Journal of Pharmaceutical Sciences”

This study concluded that sebaceous glands are the main pathway for the antiandrogen RU 58841 to permeate the skin, with liposomes enhancing localization in these glands.

research Role of Transepidermal and Transfollicular Routes in Percutaneous Absorption of Steroids: In Vitro Studies on Human Skin

82 citations , January 1994 in “Skin Pharmacology and Physiology”

This study found that human skin with hair follicles and sebaceous glands absorbed significantly more steroids than scar skin without these appendages, indicating their role in steroid penetration.