In Vivo Silica Nanoparticle Translocation Across Human Stratum Corneum: The Effect of Surface Hydrophobization in Relation to Hair Follicle Density

    January 2013 in “ IRIS UNIMORE (University of Modena and Reggio Emilia) ”
    Valentina Iannuccelli, Davide Bertelli, Marcello Romagnoli, Eleonora Maretti, Francesca Sacchetti, Eliana Leo
    TLDR Hydrophobized silica nanoparticles penetrate the skin's outer layer more effectively, while hair follicle density doesn't impact their accumulation.
    The study investigated the in vivo translocation of silica nanoparticles across the human stratum corneum (SC) and the effect of surface hydrophobization in relation to hair follicle density. Using tape stripping and EDX analysis on volunteers' forearms, it was found that silica nanoparticles could penetrate the outer SC, accumulating in the corneum disjunctum, with a significant decrease in deeper layers. The study revealed that hydrophobized silica (H-silica) enhanced penetration, suggesting that surface hydrophobization plays a role in facilitating nanoparticle movement across the SC. Hair follicle density did not significantly affect silica accumulation.
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