In Vivo Investigation of the Efficiency of a Nanoparticle-Emulsion Containing Polihexanide on Human Skin

December 2012 in “ European journal of pharmaceutics and biopharmaceutics ”

Miriam Ulmer, Alexa Patzelt, Theognosia Vergou, Heike Richter, Gerald Müller, Axel Krämer, Wolfram Sterry, V. Czaika, Juergen Lademann

nanoparticle-emulsion polihexanide hair follicles skin antisepsis bacterial growth

Studysummary This study suggests that using particle-bound antiseptics may provide more effective and longer-lasting skin antisepsis compared to their non-particulate forms.

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The study investigated the effectiveness of a nanoparticle-emulsion containing polihexanide for skin antisepsis, focusing on its ability to penetrate hair follicles, which house about 25% of the skin's resident bacteria. The in vivo experiments monitored bacterial growth over 2.5 hours post-antisepsis and found that the particle-bound antiseptic provided better and longer-lasting antisepsis compared to its non-particulate form.

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