In Vivo Investigation of the Efficiency of a Nanoparticle-Emulsion Containing Polihexanide on Human Skin

June 2013 in “ European journal of pharmaceutics and biopharmaceutics ”

Miriam Ulmer, Alexa Patzelt, Theognosia Vergou, Heike Richter, Gerald Müller, Axel Krämer, Wolfram Sterry, V. Czaika, Juergen Lademann

nanoparticle-emulsion polihexanide hair follicles skin antisepsis bacterial growth

TLDR The nanoparticle-emulsion with polihexanide is more effective and lasts longer for skin antisepsis.

The study investigated the effectiveness of a nanoparticle-emulsion containing polihexanide for skin antisepsis, focusing on its ability to penetrate hair follicles, which house about 25% of the skin's resident bacteria. The in vivo experiments monitored bacterial growth over 2.5 hours post-antisepsis and found that the particle-bound antiseptic provided better and longer-lasting antisepsis compared to its non-particulate form.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Prevention of Follicular Penetration: Barrier-Enhancing Formulations Against the Penetration of Pollen Allergens into Hair Follicles

21 citations, January 2010 in “Skin pharmacology and physiology”

Special creams can significantly reduce pollen allergens getting into hair follicles.

research Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles

316 citations, June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.

research Variations of Hair Follicle Size and Distribution in Different Body Sites

405 citations, January 2004 in “Journal of Investigative Dermatology”

Hair follicle size and distribution vary significantly across different body sites.

Related Research

1 / 1 results

research In Vivo Investigation of the Efficiency of a Nanoparticle-Emulsion Containing Polihexanide on Human Skin

21 citations, June 2013 in “European journal of pharmaceutics and biopharmaceutics”

The nanoparticle-emulsion with polihexanide is more effective and lasts longer for skin antisepsis.

In Vivo Investigation of the Efficiency of a Nanoparticle-Emulsion Containing Polihexanide on Human Skin

Research cited in this study

research Prevention of Follicular Penetration: Barrier-Enhancing Formulations Against the Penetration of Pollen Allergens into Hair Follicles

research Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles

research Variations of Hair Follicle Size and Distribution in Different Body Sites

Related Community Posts Join

community The theory that explains everything. Please help me make this big!

community Concerns about CosmeRNA safety mechanisms

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

community New and Interesting HairLoss Studies/Papers/Reviews

community Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles - PubMed

community Metal particles abraded from dermapen (or dermaroller) needles. Is it possible?

Related Research

research In Vivo Investigation of the Efficiency of a Nanoparticle-Emulsion Containing Polihexanide on Human Skin