TLDR Proretinal nanoparticles improve skin absorption and reduce irritation of topical retinoids.
The study developed proretinal nanoparticles (PRN) to enhance the percutaneous absorption and follicular penetration of retinal, addressing issues of low bioavailability, chemical instability, and skin irritation associated with topical retinoids. The PRN, made from chitosan grafted with retinal, showed significant improvement in delivering retinal to the stratum corneum and hair follicles. The nanoparticles reached the infundibular area of hair follicles and released the model drug effectively within the follicles. This nanoparticle system could potentially improve the treatment of retinoid-responsive and hair follicle-associated skin conditions like acne.
263 citations,
February 2011 in “Journal of Controlled Release” Medium-sized particles penetrate hair follicles better than smaller or larger ones, which could improve delivery of skin treatments.
119 citations,
December 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Nanoparticles can deliver vaccines through hair follicles, triggering immune responses and providing protection.
48 citations,
May 2008 in “Drug Discovery Today: Disease Mechanisms” Hair follicles offer promising targets for delivering drugs to treat hair and skin conditions.
162 citations,
August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” The new "differential stripping" method effectively measures how much substance gets into hair follicles.
Proretinal nanoparticles are a safe and effective way to deliver retinal to the skin.
April 2024 in “Cosmetics” Microneedling improves skin and hair conditions by enhancing treatment absorption and stimulating growth factors.
14 citations,
January 2016 in “Elsevier eBooks” Liposomes improve the delivery and effectiveness of cosmetic ingredients but face challenges like cost and stability.
December 2021 in “Journal of Rheumatic Diseases” Early treatment of pediatric lupus-related eye issues is crucial to prevent vision loss.
10 citations,
December 2015 in “Clinics in Dermatology” Diabetes can lead to blindness and skin problems, and managing blood sugar and blood pressure is crucial to prevent these complications.
