TLDR Nanoparticles improve drug delivery and effectiveness in treating inflamed skin.
The study demonstrated that polymeric nanoparticles (NPs) with diameters less than 100 nm selectively accumulated in inflamed skin hair follicles and sebaceous glands, enhancing drug delivery to these areas while reducing systemic side effects and exposure to healthy skin. In a mouse model of dithranol-induced dermatitis, smaller NPs showed approximately 3-fold stronger and deeper penetration in inflamed skin compared to healthy skin. Betamethasone-loaded NPs confirmed the size dependency, with smaller NPs exhibiting higher therapeutic efficiency, as evidenced by histological examination and inflammatory marker measurements. This approach suggested a promising strategy for targeted therapy in inflamed skin conditions.
323 citations,
April 2006 in “The journal of investigative dermatology/Journal of investigative dermatology” Only 40 nm nanoparticles can enter skin cells effectively for potential vaccine delivery.
316 citations,
June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.
405 citations,
January 2004 in “Journal of Investigative Dermatology” Hair follicle size and distribution vary significantly across different body sites.
36 citations,
July 2017 in “Journal of controlled release” A new method allows for controlled, long-lasting delivery of retinoic acid through the skin with fewer side effects.
119 citations,
March 2020 in “Frontiers in Bioengineering and Biotechnology” Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.
5 citations,
December 2023 in “Materials” Organic and biogenic nanocarriers can improve drug delivery but face challenges like consistency and safety.
43 citations,
July 2016 in “European journal of pharmaceutical sciences” Scientists created tiny particles that release medicine on the skin and in hair, working better at certain pH levels and being safe for skin cells.
32 citations,
June 2017 in “Journal of Pharmaceutical Sciences” Chitosan-coated nanoparticles improve skin delivery of hair loss treatments with fewer side effects.
