Nanoparticles Enhance Therapeutic Outcome in Inflamed Skin Therapy

The study demonstrated that polymeric submicron particles (NP) significantly enhanced drug delivery to inflamed skin in a mouse model of dithranol-induced dermatitis. Smaller particles (50-100 nm) showed a 3-fold stronger and deeper penetration, particularly accumulating in inflamed hair follicles and sebaceous glands. Betamethasone-loaded NPs were more therapeutically effective, as evidenced by reduced myeloperoxidase activity (0.5 ± 0.2 U/mg for NP100) compared to larger particles and untreated controls. This method potentially offers a more targeted and efficient treatment for inflamed skin, minimizing systemic side effects.