Polymer Conjugated Retinoids for Controlled Transdermal Delivery

The study explored the use of polymer-conjugated all-trans retinoic acid (ATRA) for controlled transdermal delivery by conjugating ATRA to polyvinyl alcohol (PVA), creating a water-soluble amphiphilic nanomaterial (PATRA). This approach aimed to improve ATRA's stability, solubility, and retention while reducing side effects like skin irritation and hair loss. In vitro and ex vivo tests showed that PATRA provided sustained release and higher epidermal accumulation of ATRA, while in vivo tests on mice demonstrated reduced inflammation and prolonged drug retention. The findings suggested that PATRA could enhance the efficacy and safety of topical ATRA therapies.