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    GlossaryTopical Treatments (Topical Therapies)

    medications applied directly to the skin or scalp

    Topical treatments, also known as topical agents or topical medications, are medications applied directly to a specific area of the skin or scalp to treat localized conditions. These treatments can include creams, gels, ointments, and lotions, and are commonly used for conditions like alopecia, psoriasis, and eczema, delivering active ingredients directly to the affected area to minimize systemic side effects.

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      learn Fluridil

      a topical anti-androgen with less systemic involvement

      learn Spironolactone

      powerful topical and oral anti-androgen used mostly by women

      learn Clascoterone

      a novel topical treatment that inhibits DHT on androgen receptors

      learn RU58841

      a potent but unapproved and potentially problematic topical anti-androgen

      learn Melatonin

      hormone commonly taken for sleep aid has some topical benefits for hair

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      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  743 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Tretinoin for some men(not all) can cause non-telogen effluvium hair loss

      in Research/Science  2 upvotes 2 months ago
      Tretinoin can cause non-telogen hair loss in some men by inducing catagen-like changes in hair follicles and through retinoid toxicity, especially when used with minoxidil. Some users report hair loss even when using retinoids on the face, while others experience benefits when combined with treatments like finasteride and minoxidil.

      community Haircafe on why microneedling is bad for hair growth

      in Microneedling  157 upvotes 1 year ago
      Microneedling combined with minoxidil and finasteride shows significant hair regrowth, though opinions on its effectiveness vary. Some users report substantial benefits, while others highlight the need for more research and consistency in application.

      community Topical dutasteride significantly outperforms oral finasteride

      in Research/Science  64 upvotes 5 days ago
      Topical dutasteride 0.05% is reported to outperform oral finasteride with minimal side effects, but concerns about study bias exist due to company funding. Some users report mixed results with topical dutasteride, noting issues with skin penetration and systemic absorption.