The Mechanistic Insights Into The Application Of Retinoids And Possible Adjunct Therapeutic Treatment To Androgenic Alopecia

    October 2025 in “ Annals of Medicine and Surgery ”
    Hamza Irfan, Ahmad Asad Raza, Hira Amran Chowdhry … Abedin Samadi
    Studysummary This study discusses the potential of topical retinoids, vitamin A derivatives, to improve treatment outcomes for androgenetic alopecia by promoting hair growth through extending the anagen phase and stimulating follicular activity, offering a promising approach when combined with existing therapies.
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    Research cited in this study 41

    1. The Efficacy of Tretinoin Gel 0.1% Followed by Topical Minoxidil 5% in Individuals with Androgenetic Alopecia International Journal of Research in Dermatology · 2025
    2. Clinical And Preclinical Approach In AGA Treatment: A Review Of Current And New Therapies In The Regenerative Field Stem Cell Research & Therapy · 2024
    3. Retinoic Acid Drives Hair Follicle Stem Cell Activation via Wnt/Beta-Catenin Signalling in Androgenetic Alopecia JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    4. Androgenetic Alopecia: A Review Nigerian Postgraduate Medical Journal · 2024
    5. A Review of Isotretinoin in the Treatment of Frontal Fibrosing Alopecia Journal of cosmetic dermatology · 2024
    6. Relative Efficacy of Minoxidil and the 5-Alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients JAMA Dermatology · 2022
    7. Teratogenic Effect of Isotretinoin in Both Fertile Females and Males: A Review Experimental and Therapeutic Medicine · 2021
    8. Androgenetic Alopecia in Women and Men: Italian Guidelines Adapted from European Dermatology Forum/European Academy of Dermatology and Venereology Guidelines Giornale italiano di dermatologia e venereologia · 2020
    9. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment Dermatology and therapy · 2020
    10. Efficacy and Safety of Oral Minoxidil in Female Androgenetic Alopecia Dermatologic Therapy · 2020
    11. Clascoterone as a Novel Treatment for Androgenetic Alopecia Clinical and Experimental Dermatology · 2020
    12. Efficacy of Intralesional and Oral Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review Skin appendage disorders · 2020
    13. Noncoding dsRNA Induces Retinoic Acid Synthesis to Stimulate Hair Follicle Regeneration via TLR3 Nature Communications · 2019
    14. Effectiveness and Safety of Low-Dose Oral Minoxidil in Male Androgenetic Alopecia Journal of The American Academy of Dermatology · 2019
    15. Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Upregulating Follicular Sulfotransferase Enzymes Dermatologic Therapy · 2019
    16. Sexual Dysfunction in Men Taking Systemic Dermatologic Medication: A Systematic Review Journal of The American Academy of Dermatology · 2019
    17. Increasing the Percutaneous Absorption and Follicular Penetration of Retinal by Topical Application of Proretinal Nanoparticles European journal of pharmaceutics and biopharmaceutics · 2019
    18. The Main Cause of Hair Rarefaction in Androgenetic Alopecia: Higher Number and Longer Duration of Kenogen Hairs Skin appendage disorders · 2018
    19. Androgenic Alopecia and Dutasteride in Hair Mesotherapy: A Short Review Our Dermatology Online · 2018
    20. Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride PeerJ · 2017
    21. Demographics of Women with Female Pattern Hair Loss and the Effectiveness of Spironolactone Therapy Journal of The American Academy of Dermatology · 2015
    22. The Growth of Human Scalp Hair in Females Using Visible Red Light Laser and LED Sources Lasers in Surgery and Medicine · 2014
    23. A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2014
    24. Female Pattern Alopecia: Current Perspectives International Journal of Women's Health · 2013
    25. Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology Journal of Investigative Dermatology · 2013
    26. Retinoids Putting the 'A' in Alopecia Journal of Investigative Dermatology · 2013
    27. Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
    28. A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2011
    29. S1 Guideline for Diagnostic Evaluation in Androgenetic Alopecia in Men, Women, and Adolescents British Journal of Dermatology · 2010
    30. Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study Journal of The American Academy of Dermatology · 2010
    31. Promotive Effect of Minoxidil Combined with All-Trans Retinoic Acid (Tretinoin) on Human Hair Growth In Vitro Journal of Korean Medical Science · 2007
    32. Efficacy of 5% Minoxidil Versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss American Journal of Clinical Dermatology · 2007
    33. The Additive Effects of Minoxidil and Retinol on Human Hair Growth In Vitro Biological & Pharmaceutical Bulletin · 2007
    34. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005
    35. Treatment of Female Pattern Hair Loss With Oral Antiandrogens British Journal of Dermatology · 2005
    36. Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    37. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    38. Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects Journal of The American Academy of Dermatology · 1993
    39. Influence of Tretinoin on the Percutaneous Absorption of Minoxidil from an Aqueous Topical Solution Clinical Pharmacology & Therapeutics · 1990
    40. Retinoids: Compounds Important to Hair Growth Clinics in dermatology · 1988
    41. Topical Tretinoin for Hair Growth Promotion Journal of the American Academy of Dermatology · 1986