The Mechanistic Insights Into The Application Of Retinoids And Possible Adjunct Therapeutic Treatment To Androgenic Alopecia

October 2025 in “ Annals of Medicine and Surgery ”

Hamza Irfan, Ahmad Asad Raza, Hira Amran Chowdhry, Muhammad Bin Mobin, Abedin Samadi, Ahmad Asad Raza, Abedin Samadi, Abedin Samadi

retinoids androgenetic alopecia dihydrotestosterone follicular miniaturization anagen phase vitamin A derivatives topical retinoids AGA DHT

TLDR Retinoids may improve hair growth in androgenic alopecia when used with other treatments.

Androgenetic alopecia (AGA) is a common hair loss condition influenced by genetic and androgenic factors, particularly dihydrotestosterone, leading to follicular miniaturization and a shortened anagen phase. Current treatments are often inadequate, but recent research highlights the potential of retinoids, vitamin A derivatives, in promoting hair growth by extending the anagen phase and stimulating follicular activity. Early studies indicate that topical retinoids, especially when combined with existing therapies, may enhance treatment outcomes, offering a promising direction for more effective AGA management and hair restoration.

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