The Efficacy of Tretinoin Gel 0.1% Followed by Topical Minoxidil 5% in Individuals with Androgenetic Alopecia

This study evaluated the efficacy of a combination therapy using 0.1% tretinoin gel followed by 5% minoxidil solution in 20 patients with androgenetic alopecia (AGA) who were non-responders to minoxidil alone. Over 90 days, participants experienced a 32.9% increase in hair count and density, a 3.5% rise in anagen-phase hairs, and a 4.8% increase in hair thickness. Investigator assessments showed that 20% of participants had a 51-75% improvement, while patient self-assessments indicated improvements in hair quality (50%), hair coverage (70%), and overall appearance (75%). Most participants (80%) reported new hair growth and satisfaction with the treatment, demonstrating the combination's effectiveness in enhancing hair growth and patient satisfaction in AGA cases.