The Efficacy of Tretinoin Gel 0.1% Followed by Topical Minoxidil 5% in Individuals with Androgenetic Alopecia

    June 2025 in “ International Journal of Research in Dermatology ”
    B. S. Chandrashekar, N. G. Nayana, M. S. Roopa, Nagamani Narayana
    Studysummary In this case series, researchers observed that combining 0.1% tretinoin gel with 5% minoxidil over 90 days improved hair growth and patient satisfaction in androgenetic alopecia patients who did not previously respond to minoxidil alone, with significant increases in hair count, density, and quality.
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    Research cited in this study 12

    1. Compliance to Topical Minoxidil and Reasons for Discontinuation Among Patients With Androgenetic Alopecia Dermatology and therapy · 2023
    2. SULT1A1 (Minoxidil Sulfotransferase) Enzyme Booster Significantly Improves Response to Topical Minoxidil for Hair Regrowth Journal of Cosmetic Dermatology · 2021
    3. Exploring the Potential of Minoxidil Tretinoin Liposomal-Based Hydrogel for Topical Delivery in the Treatment of Androgenic Alopecia Cutaneous and Ocular Toxicology · 2019
    4. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    5. Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Upregulating Follicular Sulfotransferase Enzymes Dermatologic Therapy · 2019
    6. Preparation and Physicochemical Characterization of Topical Niosomal Formulation of Minoxidil and Tretinoin Global journal of pharmacy & pharmaceutical sciences · 2017
    7. Novel Enzymatic Assay Predicts Minoxidil Response in the Treatment of Androgenetic Alopecia Dermatologic Therapy · 2013
    8. Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects International Journal of Trichology · 2009
    9. Promotive Effect of Minoxidil Combined with All-Trans Retinoic Acid (Tretinoin) on Human Hair Growth In Vitro Journal of Korean Medical Science · 2007
    10. Efficacy of 5% Minoxidil Versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss American Journal of Clinical Dermatology · 2007
    11. The Additive Effects of Minoxidil and Retinol on Human Hair Growth In Vitro Biological & Pharmaceutical Bulletin · 2007
    12. Influence of Tretinoin on the Percutaneous Absorption of Minoxidil from an Aqueous Topical Solution Clinical Pharmacology & Therapeutics · 1990

    Related research 2

    1. Contact Dermatitis Caused by Topical Minoxidil: Allergy or Just Irritation Acta Dermato Venereologica · 2025
    2. Comparative Study of Efficacy of Topical Minoxidil 5% and Combination of Topical Minoxidil 5%, Topical Azelaic Acid 1.5% and Topical Tretinoin 0.01% Based on Dermoscopic Analysis in Androgenetic Alopecia MVP journal of medical science · 2015