The Efficacy of Tretinoin Gel 0.1% Followed by Topical Minoxidil 5% in Individuals with Androgenetic Alopecia

    June 2025 in “ International Journal of Research in Dermatology ”
    B. S. Chandrashekar, N. G. Nayana, M. S. Roopa, Nagamani Narayana
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    TLDR The combination of tretinoin gel and minoxidil effectively improves hair growth and satisfaction in people with androgenetic alopecia.
    This study evaluated the efficacy of a combination therapy using 0.1% tretinoin gel followed by 5% minoxidil solution in 20 patients with androgenetic alopecia (AGA) who were non-responders to minoxidil alone. Over 90 days, participants experienced a 32.9% increase in hair count and density, a 3.5% rise in anagen-phase hairs, and a 4.8% increase in hair thickness. Investigator assessments showed that 20% of participants had a 51-75% improvement, while patient self-assessments indicated improvements in hair quality (50%), hair coverage (70%), and overall appearance (75%). Most participants (80%) reported new hair growth and satisfaction with the treatment, demonstrating the combination's effectiveness in enhancing hair growth and patient satisfaction in AGA cases.
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      community It’s getting worse. (4 months)

      in Update  203 upvotes 2 years ago
      The conversation discusses hair loss treatments, with users suggesting the use of finasteride daily, considering minoxidil for aggressive hair loss, and discussing the normalcy of shedding during treatment. Some users recommend adding Nizoral shampoo and switching to dutasteride for better results.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

      in Research/Science  3 upvotes 1 year ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

      community How do we only have two treatments to combat hair loss at this point in time?

      in Chat  211 upvotes 2 years ago
      The post discusses frustration over the limited and not always effective treatments for hair loss, mainly Minoxidil and Finasteride. The conversation includes mentions of potential new treatments like GT20029, HMI-115, CosmeRNA, KX-826, and microneedling, but also highlights the challenges of funding and prioritizing research in this area.

      community Minoxidil seems to not work anymore this sucks

      in Progress Pictures  32 upvotes 2 years ago
      A user reported that Minoxidil, a hair growth treatment, stopped working for them despite initial success. Other users suggested not taking breaks from the treatment, checking for fake products, trying microneedling, using oral Minoxidil, combining Minoxidil with tretinoin, and using finasteride.

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