Langerin+ Dendritic Cells In Cutaneous Fibrosis: The TGF-β1 Signaling Axis
October 2025
in “
Clinical Cosmetic and Investigational Dermatology
”
cutaneous fibrosis hypertrophic scars keloids Langerin+ dendritic cells TGF-β1 keratinocyte integrins cytokine gate YAP/TAZ fibroblast activation matrix stiffening αv integrin mechanotransduction skin fibrosis scar tissue immune cells transforming growth factor beta 1 skin cells cell signaling Yes-associated protein transcriptional coactivator with PDZ-binding motif cell activation tissue stiffening integrin cell mechanics
Studysummary This study synthesizes knowledge of how dendritic cell signals, epithelial integrins, and fibroblast activity converge on TGF-β1 to maintain or disrupt skin healing, contrasting normal and fibrotic scar formation and suggesting possible integrin and immune-targeted treatments for skin fibrosis.
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