Loss of Langerhans Cells in Scar Lesion of Lichen Planopilaris Is Caused by Downregulation of Integrin αvβ6 in the Epidermal Keratinocytes

    September 2017 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Manao Kinoshita, Youichi Ogawa, Tatsuyoshi Kawamura, Shinji Shimada
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    Studysummary This study reports that the loss of Langerhans cells in lichen planopilaris scars may be linked to the downregulation of ITG αvβ6, which is not seen in other scar formation diseases. Our plain-language summary of this paper — not a Tressless recommendation.
    The document included a study that discovered the loss of Langerhans cells in the scar lesions of lichen planopilaris (LPP) is caused by the downregulation of integrin αvβ6 in epidermal keratinocytes. This downregulation potentially leads to a reduction in autocrine TGF-β, which is necessary for the maintenance of Langerhans cells. The study utilized immunohistochemistry on skin samples from LPP patients and differentiated the findings from those of other scar formation diseases, establishing that this mechanism is specific to LPP. The document also covered other research topics, such as the role of OLR1 in skin signaling, CCR5 blockade in alopecia areata, glycogen metabolism in hair follicles, the effects of cannabidiol on hair growth, and adiponectin signaling in lipid production of sebocytes.
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