Polymer Conjugated Retinoids for Controlled Transdermal Delivery

    July 2017 in “ PMC ”
    Steven Castleberry, Mohiuddin Quadir, Malak Abu Sharkh, Kevin E. Shopsowitz, Paula T. Hammond
    TLDR A new method allows for controlled, long-lasting delivery of retinoic acid through the skin with less inflammation.
    The study presented a novel method for the topical delivery of all-trans retinoic acid (ATRA) by covalently bonding it to polyvinyl alcohol (PVA), creating a water-soluble amphiphilic nanomaterial. This PVA-bound ATRA acted as a pro-drug, allowing for sustained and controlled release of active ATRA, reducing adverse side effects such as skin irritation and hair loss. In vitro tests showed that active ATRA was released for up to 10 days, and in vivo tests demonstrated reduced inflammation and retention of the drug at the application site for up to six days. This approach significantly enhanced dermal accumulation of ATRA in explant pig skin.
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