A Study on the Effectiveness and Safety of Herbal Extract Combination Compared to 3% Minoxidil Solution for the Treatment of Androgenetic Alopecia: A Randomized, Double-Blind, Controlled Trial

    June 2024 in “ ˜The œOpen dermatology journal ”
    Nutjira Cheyasak, Thitiwut Hu, Sasipa Jaruchanapongtorn … Siriwan Palawisuth
    Studysummary In this study, researchers reported that an herbal extract with dihydroquercetin glucoside, epigallocatechin gallate glucoside, zinc, and glycine showed similar effectiveness and safety to minoxidil in treating androgenetic alopecia over 24 weeks, with no significant differences in hair growth outcomes between the groups.
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    Research cited in this study 12

    1. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    2. An Overview of Herbal Alternatives in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2019
    3. Serum Biotin and Zinc in Male Androgenetic Alopecia Journal of Cosmetic Dermatology · 2019
    4. Androgenetic Alopecia: A Review Endocrine · 2017
    5. Low Plasma Zinc Levels in Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2017
    6. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    7. Polyphenols as Novel Treatment Options for Dermatological Diseases: A Systematic Review of Clinical Trials Journal of Dermatological Treatment · 2014
    8. Analysis of Serum Zinc and Copper Concentrations in Hair Loss Annals of Dermatology · 2013
    9. Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG) Phytomedicine · 2006
    10. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    11. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    12. Isolation and Characterization of Mouse High-Glycine/Tyrosine Proteins Journal of Biological Chemistry · 1997

    Related research 8

    1. Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2023
    2. Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Upregulating Follicular Sulfotransferase Enzymes Dermatologic Therapy · 2019
    3. The Use of Minoxidil in the Treatment of Male and Female Androgenetic Alopecia: A Story of More Than 30 Years Italian journal of dermatology and venereology · 2018
    4. Scalp Psoriasiform Contact Dermatitis with Acute Telogen Effluvium Due to Topical Minoxidil Treatment Skin appendage disorders · 2015
    5. Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-Month Randomized Trial 2010
    6. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    7. Androgenetic Alopecia: Treatment Results with Topical Minoxidil Journal of The American Academy of Dermatology · 1987
    8. Topical Minoxidil Therapy and Hair Regrowth Archives of Dermatology · 1985