Sex Differences in Clinical Trials of ALRV5XR Treatment of Androgenetic Alopecia and Telogen Effluvium

August 2022 in “ Frontiers in Medicine ”

Peter D. Feldman, Oriel J. Feldman, Jaime Guevara-Aguirre, Klaus M. Fiebig

ALRV5XR androgenetic alopecia telogen effluvium terminal hair dormant follicles vellus-like hairs AGA TE TH

TLDR ALRV5XR effectively promotes hair regrowth in both men and women through different mechanisms.

The study on ALRV5XR treatment for androgenetic alopecia (AGA) and telogen effluvium (TE) in 92 subjects (46 women and 46 men) over 24 weeks showed significant increases in terminal hair (TH) density, with women experiencing a 30.1 THs/cm² increase and men a 21.0 THs/cm² increase. Women primarily regrew hair from dormant follicles, while men showed equal regrowth from dormant follicles and thickening of vellus-like hairs. The treatment was well-tolerated with no adverse events, and women had a higher response rate (67%) compared to men (100%). The study concluded that ALRV5XR effectively promotes hair regrowth through different mechanisms in men and women.

View this study on frontiersin.org →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research Safety and Efficacy of ALRV5XR in Men with Androgenetic Alopecia: A Randomised, Double-Blinded, Placebo-Controlled Clinical Trial

3 citations, September 2021 in “EClinicalMedicine”

ALRV5XR effectively increases hair density in men with androgenetic alopecia without adverse effects.

research Safety and Efficacy of ALRV5XR in Women with Androgenetic Alopecia or Telogen Effluvium: A Randomised, Double-Blinded, Placebo-Controlled Clinical Trial

6 citations, June 2021 in “EClinicalMedicine”

ALRV5XR significantly improves hair density in women with hair loss and is well-tolerated.

AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the Use of Platelet-Rich Plasma (PRP) and Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing

research AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the Use of Platelet-Rich Plasma (PRP) and Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing

17 citations, March 2021 in “Expert Opinion on Biological Therapy”

Use PRP and ASC-BT for hair loss and wound healing, but more research needed.

research Male and Female Pattern Hair Loss: Treatable and Worth Treating

11 citations, March 2021 in “Cleveland Clinic Journal of Medicine”

Treating hair loss in both men and women is effective and improves quality of life.

Exhaustive Analysis of Scalp Hair Regression: Subjective and Objective Perception from Initial Hair Loss to Severe Miniaturization and Drug-Induced Regrowth

research Exhaustive Analysis of Scalp Hair Regression: Subjective and Objective Perception from Initial Hair Loss to Severe Miniaturization and Drug-Induced Regrowth

3 citations, January 2021 in “Plastic and Aesthetic Research”

Hair loss reduces hair thickness and coverage, but drug treatments mainly revive dormant hairs rather than reverse thinning; patients often undervalue their hair loss severity.

Placebo-Controlled Dose-Effect Studies with Topical Minoxidil 2% or 5% in Male-Patterned Hair Loss Treated with Oral Finasteride Employing an Analytical and Exhaustive Study Protocol

research Placebo-Controlled Dose-Effect Studies with Topical Minoxidil 2% or 5% in Male-Patterned Hair Loss Treated with Oral Finasteride Employing an Analytical and Exhaustive Study Protocol

5 citations, January 2020 in “Skin Research and Technology”

Minoxidil 5% works better than 2% for hair growth in male-patterned hair loss.

research Age-Related Hair Changes in Men: Mechanisms and Management of Alopecia and Graying

37 citations, October 2014 in “Maturitas”

Men's hair loss is caused by hormones and genes, and can be treated with medication and surgery, while graying is due to aging and has no prevention except dyeing.

Related Research

9 / 9 results

The Predictive Value of Midscalp Hair Density and Terminal Hair Percentage in the Severity Evaluation of Female Pattern Hair Loss Assessed by Trichoscan in a Sample of Chinese Population

research The Predictive Value of Midscalp Hair Density and Terminal Hair Percentage in the Severity Evaluation of Female Pattern Hair Loss Assessed by Trichoscan in a Sample of Chinese Population

1 citations, December 2022 in “Clinical, Cosmetic and Investigational Dermatology”

Midscalp hair density and terminal hair percentage are good indicators of female pattern hair loss severity.

research Sex Differences in Clinical Trials of ALRV5XR Treatment of Androgenetic Alopecia and Telogen Effluvium

1 citations, August 2022 in “Frontiers in Medicine”

ALRV5XR effectively promotes hair regrowth in both men and women through different mechanisms.

research Hair and Nail Conditions: Alopecia Evaluation

1 citations, June 2022 in “PubMed”

Alopecia causes hair loss and should be treated early, especially scarring types where hair cannot regrow.

research Hair Trichology Treatment

January 2020 in “Hair therapy & transplantation”

Healthy hair and scalp depend on overall body health.

research Parietal Scalp Is Another Affected Area in Female Pattern Hair Loss: An Analysis of Hair Density and Hair Diameter

30 citations, December 2017 in “Clinical, Cosmetic and Investigational Dermatology”

Parietal scalp area has lower hair density and smaller hair diameter in women with hair loss.

research Characteristics of Korean Scalp Hair and Male Pattern Baldness

January 2013 in “Journal of The Korean Medical Association”

The document's conclusion cannot be provided because the text is in Korean and cannot be parsed.

research Hair and Scalp Diseases

12 citations, February 2008 in “CRC Press eBooks”

The document explains different hair and scalp conditions and their treatments.

research Increased Hair Shedding May Be Associated with the Presence of Malassezia

9 citations, January 2006 in “American Journal of Clinical Dermatology”

Malassezia yeast might be linked to more hair shedding.

research Topical Minoxidil in Androgenetic Alopecia: Scandinavian and Middle East Experience

11 citations, July 1988 in “International Journal of Dermatology”

The study found that using 2% minoxidil solution can help grow hair and is safe.