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Research

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research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

1707 citations , December 2003 in “The New England Journal of Medicine”

Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.

research Stem Cells and Their Niches

1549 citations , March 2006 in “Science”

This review discusses the stem cell niche concept in mammalian systems and reports no new clinical results, highlighting recent progress and identifying important unanswered questions.

research The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report

1540 citations , October 2008 in “Fertility and Sterility”

This review discusses the definition of polycystic ovary syndrome proposed by the AE-PCOS Society Task Force, emphasizing hyperandrogenism, ovarian dysfunction, and excluding related disorders, while noting potential variations needing more research.

research The Rotterdam Study: objectives and design update

1415 citations , October 2007 in “European Journal of Epidemiology”

This article reviews the objectives and design of the Rotterdam Study and summarizes key findings across its focus on various diseases, without reporting new experimental results.

research The human keratins: biology and pathology

1398 citations , May 2008 in “Histochemistry and Cell Biology”

This review summarizes the cell type distribution and functional significance of human keratins, emphasizing their roles in tumor diagnosis and potential clinical applications, and reports no new clinical findings.

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Community Join

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community 9 months of treatment as an aggressive diffuse thinner

67 upvotes 4 months ago

The user has been using oral minoxidil, dutasteride, RU58841, and other treatments for hair loss over nine months, seeing some improvement in hair thickness and crown volume but continued thinning at the hairline. They plan to continue treatment for another nine months despite being sensitive to DHT fluctuations and are considering increasing dosages or other options like a hair transplant.

community Three years in and the thing that nearly ended it was routine. How do you actually stay consistent?

2 upvotes 16 hours ago

The conversation is about maintaining consistency in hair loss treatment routines, specifically using minoxidil and finasteride. Users discuss challenges with topical application and share solutions like switching to oral medications for easier adherence.

community diffuse thinning is so much worse than recession

14 upvotes 1 day ago

The conversation discusses hair loss treatments, specifically using 2.5mg dutasteride, minoxidil, and sometimes RU58841, with a focus on diffuse thinning versus recession. It also touches on the impact of estrogen levels on hair density.

community any guys with previously long, thick hair who are dealing with androgenic alopecia? 😭

96 upvotes 1 day ago

The user is dealing with androgenic alopecia and has been using finasteride and minoxidil for six months, which has stopped hair loss and started regrowth. The user expresses concern about the impact of hair loss on their self-image and future career plans.

community Thoughts ? 10 1/2 months on meds

2 upvotes 1 day ago

The user has been using 2.5mg oral Minoxidil and 1mg Finasteride for 10.5 months and is seeking opinions on their hairline, which others agree looks good and is around Norwood 1.5. Finasteride is praised for effectively stopping hair loss.

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Learn

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learn thyme

learn threonine

learn Thymosin Beta 4

learn thiamin

learn Ketoconazole

Is there a difference between 1% and 2% ketoconazole? The documented differences are strength and supply: 1% ketoconazole shampoo is sold over the counter while 2% is usually prescription-only, and almost all of the trial evidence — including a 2015 Cochrane review — was gathered on the 2% shampoo rather than in a head-to-head comparison of the two strengths.

learn Capixyl

Capixyl: Can it replace minoxidil or do they have to be used together? There is no published trial comparing Capixyl with minoxidil or testing the two together; the evidence for Capixyl is a manufacturer-run study of 30 people, while minoxidil is an approved treatment with decades of controlled trials behind it.

learn GHK-Cu

GHK-Cu: Is it better than minoxidil or finasteride, or just a complement? There is no completed human trial of GHK-Cu for androgenetic alopecia, so it cannot be compared with minoxidil or finasteride on evidence; clinics and community users treat it as an unproven add-on, not a replacement.

learn Redensyl

Does Redensyl prevent hair loss or only help when there's already visible hair loss? The only human data on Redensyl is a small, unpublished manufacturer study in men who already had androgenetic alopecia; there is no evidence in people without visible hair loss, so nothing supports using it to prevent hair loss before it starts.

learn Vitamin B1

Thinning hair over time? It might not just be genetics: lack of B1 and B2 could be silently working against you. There is no verified human trial showing that B1 or B2 deficiency causes thinning hair or that correcting it regrows hair; a 2019 review concludes the role of micronutrients in hair loss is real but unclear and still needs controlled trials.