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    Glossary Pharmacokinetics

    study of how drugs move through the body

    Pharmacokinetics (PK) is the study of how a drug moves through the body over time. It involves four main processes: absorption (how the drug enters the bloodstream), distribution (how the drug spreads through the body's tissues), metabolism (how the body breaks down the drug), and excretion (how the drug is eliminated from the body). Understanding PK helps in determining the appropriate dosage and frequency of medication to ensure its effectiveness and safety.

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    1. Pharmacokinetics, toxicity, and activity of intravenous dextran sulfate in human immunodeficiency virus infection Antimicrobial Agents and Chemotherapy · 1991 · 142 citations
    2. Pharmacokinetic studies of minoxidil Clinical Pharmacology & Therapeutics · 1972 · 90 citations
    3. ORIGINAL RESEARCH—ENDOCRINOLOGY: Comparison of the Steady‐State Pharmacokinetics, Metabolism, and Variability of a Transdermal Testosterone Patch Versus a Transdermal Testosterone Gel in Hypogonadal Men ˜The œjournal of sexual medicine · 2005 · 38 citations
    4. The effect of St. John’s wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men European Journal of Pharmaceutical Sciences · 2008 · 33 citations
    5. Pharmacokinetics of a new testosterone transdermal delivery system, TDS<sup>®</sup>‐testosterone in healthy males British Journal of Clinical Pharmacology · 2005 · 33 citations
    6. Preparation of finasteride capsules-loaded drug nanoparticles: formulation, optimization, in vitro, and pharmacokinetic evaluation International Journal of Nanomedicine · 2016 · 28 citations
    7. The Pharmacokinetics of 2.5- to 10-mg Oral Doses of Minoxidil in Healthy Volunteers The Journal of Clinical Pharmacology · 1989 · 25 citations
    8. Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone. Biochemical Pharmacology · 2001 · 22 citations
    9. Rapid determination of finasteride in human plasma by UPLC–MS/MS and its application to clinical pharmacokinetic study Journal of Chromatography B · 2010 · 18 citations
    10. A regulatory perspective on pharmacokinetic/pharmacodynamic modelling Statistical Methods in Medical Research · 1999 · 18 citations
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