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GlossaryPharmacogenetics

study of how genes affect individual responses to medications

Pharmacogenetics is the study of how an individual's genetic makeup affects their response to drugs. This field aims to tailor medical treatments to each person’s genetic profile, enhancing drug efficacy and minimizing adverse effects. It is also known as pharmacogenomics, and involves testing specific genes to predict how a patient will respond to certain medications.

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research A Study on the Clinical Profile and Pharmacogenetics of Methotrexate Treatment in Patients with Rheumatoid Arthritis

April 2014

The 1298CC genotype in RA patients leads to higher methotrexate toxicity, while the 1298AA genotype results in better treatment response.

research Pharmacogenetic Analysis of Human Steroid 5α Reductase Type II: Comparison of Finasteride and Dutasteride

26 citations, June 2005 in “Journal of Molecular Endocrinology”

Dutasteride is more efficient than finasteride, but individual results vary.

research Spontaneous Cutaneous Adverse Drug Reaction Reports: An Analysis of a 10-Year Dataset in Singapore

13 citations, March 2019 in “Pharmacology Research & Perspectives”

In Singapore, most skin reactions to drugs were in females and Chinese, often caused by painkillers, antibiotics, and some other drugs, with serious cases linked to genetics.

research Drug Eruptions in Dermatology

11 citations, June 2011 in “Expert Review of Dermatology”

Skin reactions to drugs are common and can be deadly, usually requiring stopping the drug and may be better prevented with genetic testing in the future.

research Genomic Markers and Personalized Medicine in Androgenetic Alopecia: A Comprehensive Review

August 2024 in “Cosmetics”

Personalized treatments for hair loss are becoming more effective by using genetic information.

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community 35% regrowth brothers and sisters! More effective than Minox and Fin?

in Treatment 107 upvotes 6 years ago

A double-blind clinical study that found ingestion of tocotrienols resulted in a 34.5% increase in hair regrowth compared to the placebo group, and discussion about potential side effects and cost of supplementation with vitamin E pills. The conversation noted that it may be more effective than commonly used treatments like minoxidil and finasteride.

community Switching to Oral from Topical min effective or not

in Minoxidil 4 upvotes 1 week ago

Switching from topical to oral minoxidil may lead to better results for some users, with oral minoxidil generally being more effective due to higher absorption. However, it can also cause side effects like hypertrichosis and blood pressure issues, and individual responses may vary.

community Methods Of Staying Safe On Ru58841 - My 2 Cents

in Research/Science 16 upvotes 3 months ago

RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.

community Research Backed Dutasteride Simulator (Serum/scalp DHT included for all doses)

in Research 489 upvotes 4 months ago

A Dutasteride Simulator predicts serum dutasteride, serum DHT, and scalp DHT levels using models from research papers. It simulates various dosing schedules to determine steady-state effects and visualizes outcomes, including hair growth-related scalp DHT suppression.

community Research Backed Dutasteride Simulator (Serum/Scalp DHT included for all doses)

in Finasteride/Dutasteride 112 upvotes 4 months ago

A dutasteride simulator predicts that daily 0.5 mg dosing results in higher DHT suppression compared to less frequent dosing. Twice-weekly dutasteride may be as effective as finasteride 5 mg, providing a balance between efficacy and ease of use.

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