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    Glossary Pharmacokinetics

    study of how drugs move through the body

    Pharmacokinetics (PK) is the study of how a drug moves through the body over time. It involves four main processes: absorption (how the drug enters the bloodstream), distribution (how the drug spreads through the body's tissues), metabolism (how the body breaks down the drug), and excretion (how the drug is eliminated from the body). Understanding PK helps in determining the appropriate dosage and frequency of medication to ensure its effectiveness and safety.

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    Research 30 of 1000+

    1. Pharmacokinetics, toxicity, and activity of intravenous dextran sulfate in human immunodeficiency virus infection Antimicrobial Agents and Chemotherapy · 1991 · 142 citations
    2. Pharmacokinetic studies of minoxidil Clinical Pharmacology & Therapeutics · 1972 · 90 citations
    3. ORIGINAL RESEARCH—ENDOCRINOLOGY: Comparison of the Steady‐State Pharmacokinetics, Metabolism, and Variability of a Transdermal Testosterone Patch Versus a Transdermal Testosterone Gel in Hypogonadal Men ˜The œjournal of sexual medicine · 2005 · 38 citations
    4. The effect of St. John’s wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men European Journal of Pharmaceutical Sciences · 2008 · 33 citations
    5. Pharmacokinetics of a new testosterone transdermal delivery system, TDS<sup>®</sup>‐testosterone in healthy males British Journal of Clinical Pharmacology · 2005 · 33 citations
    6. Preparation of finasteride capsules-loaded drug nanoparticles: formulation, optimization, in vitro, and pharmacokinetic evaluation International Journal of Nanomedicine · 2016 · 28 citations
    7. The Pharmacokinetics of 2.5- to 10-mg Oral Doses of Minoxidil in Healthy Volunteers The Journal of Clinical Pharmacology · 1989 · 25 citations
    8. Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone. Biochemical Pharmacology · 2001 · 22 citations
    9. Rapid determination of finasteride in human plasma by UPLC–MS/MS and its application to clinical pharmacokinetic study Journal of Chromatography B · 2010 · 18 citations
    10. A regulatory perspective on pharmacokinetic/pharmacodynamic modelling Statistical Methods in Medical Research · 1999 · 18 citations
    11. Pharmacokinetics of a transdermal testosterone cream in healthy postmenopausal women Menopause · 2014 · 18 citations
    12. Saturable Binding of Finasteride to Steroid 5α-reductase as Determinant of Nonlinear Pharmacokinetics Drug Metabolism and Pharmacokinetics · 2010 · 16 citations
    13. A rapid, simple, specific liquid chromatographic–electrospray mass spectrometry method for the determination of finasteride in human plasma and its application to pharmacokinetic study Journal of Pharmaceutical and Biomedical Analysis · 2006 · 15 citations
    14. Simultaneous Determination of Quercitrin, Afzelin, Amentoflavone, Hinokiflavone in Rat Plasma by UFLC–MS-MS and Its Application to the Pharmacokinetics of Platycladus orientalis Leaves Extract Journal of Chromatographic Science · 2018 · 15 citations
    15. Effect of Type 2 Diabetes Mellitus on the Pharmacokinetics of Metformin in Obese Pregnant Women Clinical Pharmacokinectics · 2012 · 10 citations
    16. Sublingual tofacitinib for alopecia areata: a roll‐over pilot clinical trial and analysis of pharmacokinetics International Journal of Dermatology · 2021 · 9 citations
    17. Pharmacokinetic Interaction of Finasteride With Tamsulosin Hydrochloride: An Open-label, Randomized, 3-period Crossover Study in Healthy Chinese Male Volunteers Clinical Therapeutics · 2014 · 7 citations
    18. Pharmacokinetics of Modified Slow-Release Oral Testosterone Over 9 Days in Normal Men With Experimental Hypogonadism International Journal of Andrology · 2012 · 7 citations
    19. Pharmacokinetic-pharmacodynamic modeling approach for dose prediction of the optimal long-acting injectable formulation of finasteride International Journal of Pharmaceutics · 2021 · 6 citations
    20. Pharmacokinetic Interaction between Finasteride and Terazosin, but not Finasteride and Doxazosin The Journal of Clinical Pharmacology · 1998 · 6 citations
    21. Pharmacokinetics of 2 Novel Formulations of Modified-Release Oral Testosterone Alone and With Finasteride in Normal Men With Experimental Hypogonadism International Journal of Andrology · 2010 · 6 citations
    22. A rapid, simple, liquid chromatographic-electrospray ionization, ion trap mass spectrometry method for the determination of finasteride in human plasma and its application to pharmacokinetic study. PubMed · 2012 · 5 citations
    23. The efficacy and safety of valproic acid medications with controlled active ingredient release in adults in real clinical practice from the position of pharmacokinetic and pharmacogenetic approaches Nevrologiâ, nejropsihiatriâ, psihosomatika · 2017 · 5 citations
    24. Development and Qualification of a Physiologically Based Pharmacokinetic Model of Finasteride and Minoxidil Following Scalp Application Journal of Pharmaceutical Sciences · 2021 · 4 citations
    25. Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women Reproductive Sciences · 2018 · 3 citations
    26. Unlocking Dithranol’s Potential: Advanced Drug Delivery Systems for Improved Pharmacokinetics International Journal of Drug Delivery Technology · 2024 · 2 citations
    27. Food Administration and Not Genetic Variants Causes Pharmacokinetic Variability of Tadalafil and Finasteride Journal of personalized medicine · 2023 · 1 citations
    28. Finasteride Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry. Application to a Comparative Pharmacokinetics Study Drug research · 2015 · 1 citations
    29. Pharmacokinetics and Bioequivalence of Finasteride Tablets in Healthy Subjects Zhongguo yaoke daxue xuebao · 2003 · 1 citations
    30. Pharmacokinetics of Finasteride in the Elderly Volunteers. Yakubutsu dōtai · 1995 · 1 citations