Synergistic Protective Effect of Finasteride and Black Soybean Extract Against Dihydrotestosterone-Induced Damage in Human Follicle Dermal Papilla Cells

January 2025 in “ Journal of the Korean Society of Food Science and Nutrition ”

Min‐Ji Kim, Sung Do Lee, Hana Lee, Seonghwa Hong, Younghwa Kim, Heon Sang Jeong, Junsoo Lee

finasteride black soybean extract dihydrotestosterone human follicle dermal papilla cells androgenetic alopecia pro-inflammatory cytokines TNF-α IL-6 DHT AGA

TLDR Combining finasteride and black soybean extract better protects hair cells from damage and may treat hair loss effectively with fewer side effects.

The study explores the synergistic effects of combining finasteride and black soybean extract (BSE) to protect human follicle dermal papilla cells from dihydrotestosterone (DHT)-induced damage, which is relevant to hair growth and androgenetic alopecia (AGA). The optimal 6:4 ratio of finasteride to BSE significantly increased cell viability to 90% compared to 73% with either treatment alone. This combination also reduced pro-inflammatory cytokines TNF-α and IL-6, suggesting enhanced therapeutic potential for AGA with lower drug doses and fewer side effects. The findings highlight the promise of this combination as a treatment strategy for AGA by leveraging the pharmacological properties of both substances.

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