Synergistic Protective Effect of Finasteride and Black Soybean Extract Against Dihydrotestosterone-Induced Damage in Human Follicle Dermal Papilla Cells
January 2025
in “
Journal of the Korean Society of Food Science and Nutrition
”
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Studysummary This study found that the combination of finasteride and black soybean extract showed synergistic protective effects against DHT-induced damage in hair follicle cells, suggesting potential benefits for treating androgenetic alopecia. Our plain-language summary of this paper — not a Tressless recommendation.
The study explores the synergistic effects of combining finasteride and black soybean extract (BSE) to protect human follicle dermal papilla cells from dihydrotestosterone (DHT)-induced damage, which is relevant to hair growth and androgenetic alopecia (AGA). The optimal 6:4 ratio of finasteride to BSE significantly increased cell viability to 90% compared to 73% with either treatment alone. This combination also reduced pro-inflammatory cytokines TNF-α and IL-6, suggesting enhanced therapeutic potential for AGA with lower drug doses and fewer side effects. The findings highlight the promise of this combination as a treatment strategy for AGA by leveraging the pharmacological properties of both substances.
