Nongenomic Effects of 1α,25-Dihydroxyvitamin D3 on Cartilage Formation Deduced from Comparisons Between Cyp27b1 and Vdr Knockout Mice

    January 2017 in “ Biochemical and biophysical research communications ”
    Yoshio Hirota, Kimie Nakagawa, Shino Mimatsu, Natsumi Sawada, Toshiyuki Sakaki, Noboru Kubodera, Maya Kamao, Naoko Tsugawa, Yoshitomo Suhara, Toshio Okano
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    TLDR 1α,25-dihydroxyvitamin D3 directly affects cartilage growth and development.
    The study compared Cyp27b1−/− mice, deficient in CYP27B1, with VDR-deficient mice (Vdr−/−) to understand the physiological significance of 1α,25-dihydroxyvitamin D3 (1α,25D3) and its receptor. Both types of mice exhibited hypocalcemia, growth defects, and skeletogenesis dysfunction, but only Vdr−/− mice developed alopecia. Cyp27b1−/− mice also showed cartilage mass formation and walking difficulties. Even with corrected blood calcium levels, growth and cartilage abnormalities persisted in Cyp27b1−/− mice, indicating that 1α,25D3 directly influences chondrocyte proliferation and differentiation. This study provided a valuable animal model for developing new vitamin D formulations for osteoporosis treatment and prevention.
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