Nongenomic Effects of 1α,25-Dihydroxyvitamin D3 on Cartilage Formation Deduced from Comparisons Between Cyp27b1 and Vdr Knockout Mice

January 2017 in “ Biochemical and biophysical research communications ”

Yoshio Hirota, Kimie Nakagawa, Shino Mimatsu, Natsumi Sawada, Toshiyuki Sakaki, Noboru Kubodera, Maya Kamao, Naoko Tsugawa, Yoshitomo Suhara, Toshio Okano

1α,25-dihydroxyvitamin D3 CYP27B1 VDR alopecia chondrocyte proliferation chondrocyte differentiation vitamin D3 vitamin D receptor

TLDR 1α,25-dihydroxyvitamin D3 directly affects cartilage growth and development.

The study compared Cyp27b1−/− mice, deficient in CYP27B1, with VDR-deficient mice (Vdr−/−) to understand the physiological significance of 1α,25-dihydroxyvitamin D3 (1α,25D3) and its receptor. Both types of mice exhibited hypocalcemia, growth defects, and skeletogenesis dysfunction, but only Vdr−/− mice developed alopecia. Cyp27b1−/− mice also showed cartilage mass formation and walking difficulties. Even with corrected blood calcium levels, growth and cartilage abnormalities persisted in Cyp27b1−/− mice, indicating that 1α,25D3 directly influences chondrocyte proliferation and differentiation. This study provided a valuable animal model for developing new vitamin D formulations for osteoporosis treatment and prevention.

View this study on sciencedirect.com →

Discuss this study in the Community →

Similar Research

5 / 632 results

research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

1533 citations, October 2008 in “Endocrine reviews”

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

research Vitamin D: More Than a Bona Fide Hormone

276 citations, April 2003 in “Molecular endocrinology”

Vitamin D is important for bones, hair, blood pressure, and breast development.

research Vitamin D Resistance

45 citations, December 2006 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

Vitamin D and its receptor are essential for hair growth, cell regulation, immune function, and heart health.

research Genetic Disorders and Defects in Vitamin D Action

151 citations, June 2010 in “Endocrinology and metabolism clinics of North America”

Two rare genetic diseases cause severe rickets in children due to defects in vitamin D metabolism.

research Mutations in the Vitamin D Receptor and Hereditary Vitamin D-Resistant Rickets

107 citations, March 2014 in “BoneKEy Reports”

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

Nongenomic Effects of 1α,25-Dihydroxyvitamin D3 on Cartilage Formation Deduced from Comparisons Between Cyp27b1 and Vdr Knockout Mice

Related Community Posts Join

community For Once and For All: Is It the DHT in the Scalp That Matters, Not the DHT in Your Bloodstream?

community Fats on your Head to Stop Hair Loss?

community New Treatments, and a Huge Group Buy with Lots of Research