Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin
November 2024
vitamin D receptor VDR keratinocyte alopecia hyperkeratosis trans-epidermal water loss Shh signaling pathway Wnt signaling pathway Bmp signaling pathway hair keratins epidermal keratins keratinocyte differentiation keratinocyte proliferation keratinocyte cell death hair follicles epidermis skin homeostasis hair cycle skin abnormalities
Studysummary This study demonstrated that a ligand-independent action of the vitamin D receptor significantly affects keratinocyte behavior in hair follicles and skin, pointing to its crucial role in maintaining normal hair and skin structures in rats.
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