Gene Therapy for Alopecia in Type II Rickets Model Rats Using Vitamin D Receptor-Expressing Adenovirus Vector

October 2023 in “ Scientific Reports ”

Satoko Kise, Ayano Iijima, Chika Nagao, Tadashi Okada, Miyu Nishikawa, Shinichi Ikushiro, Teruyuki Nakanishi, Shigeto Sato, Kaori Yasuda, Toshiyuki Sakaki

gene therapy alopecia vitamin D receptor adenovirus vector VDR gene Vdr-KO rats vitamin D-dependent type II rickets hair growth hair loss cyst formation inflammation

TLDR Gene therapy helped rats with a specific type of rickets grow hair without severe inflammation.

The study investigated gene therapy as a potential treatment for alopecia in rats with vitamin D-dependent type II rickets (VDDRII). The researchers used an adenoviral vector to deliver the vitamin D receptor (VDR) gene to the cells of Vdr-KO rats, a model for VDDRII. The study involved 12 rats: 4 non-infected Vdr-KO rats, 2 Vdr-KO rats infected with control-AdV, and 6 Vdr-KO rats infected with VDR-AdV. The VDR-AdV-infected rats showed significant hair growth, reduced hair loss, and low cyst formation. The effect of VDR-AdV lasted for nearly 60 days without causing severe inflammation. The study concluded that gene therapy with AdV could be useful for alopecia caused by VDR deficiency.

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Research cited in this study

6 / 6 results

research Functional Analysis of Vitamin D Receptor Using Adenovirus Vector

4 citations, February 2023 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

The study found that certain mutations in the vitamin D receptor can cause rickets and potentially affect hair growth.

research Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices

214 citations, April 2017 in “Cell”

Different small areas within hair follicles send specific signals that control what type of cells stem cells become.

research Mutations in the Vitamin D Receptor and Hereditary Vitamin D-Resistant Rickets

107 citations, March 2014 in “BoneKEy Reports”

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

research Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor

37 citations, April 2011 in “Journal of Biological Chemistry”

LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.

research Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice

53 citations, May 2010 in “Journal of Cellular Physiology”

Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

1533 citations, October 2008 in “Endocrine reviews”

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

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research Gene Therapy for Alopecia in Type II Rickets Model Rats Using Vitamin D Receptor-Expressing Adenovirus Vector

April 2023 in “Research Square (Research Square)”

Gene therapy with a vitamin D receptor gene improved hair growth in rats with a type of rickets-related baldness.

research The Roles of Non-Coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives

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research Towards a Molecular Understanding of Hair Loss and Its Treatment

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Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

research An Induced Pluripotent Stem Cell-Based Approach for Hair Follicle Development and Regeneration

June 2024 in “Regenerative Therapy”

iPSCs show promise for hair regeneration but need more research to improve reliability and effectiveness.

research Effect of Adenovirus-Mediated Expression of Sonic Hedgehog Gene on Hair Regrowth in Mice With Chemotherapy-Induced Alopecia

39 citations, December 2001 in “JNCI: Journal of the National Cancer Institute”

Using a gene therapy with the Sonic Hedgehog gene helps mice regrow hair faster after losing it from chemotherapy.

Gene Therapy for Alopecia in Type II Rickets Model Rats Using Vitamin D Receptor-Expressing Adenovirus Vector

Research cited in this study

research Functional Analysis of Vitamin D Receptor Using Adenovirus Vector

research Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices

research Mutations in the Vitamin D Receptor and Hereditary Vitamin D-Resistant Rickets

research Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor

research Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice

research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

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