Gene Therapy for Alopecia in Type II Rickets Model Rats Using Vitamin D Receptor-Expressing Adenovirus Vector

April 2023 in “ Research Square (Research Square) ”

Satoko Kise, Ayano Iijima, Chika Nagao, Tadashi Okada, Miyu Nishikawa, Shinichi Ikushiro, Teruyuki Nakanishi, Shigeto Sato, Kaori Yasuda, Toshiyuki Sakaki

gene therapy alopecia type II rickets vitamin D receptor adenovirus vector VDR gene Vdr-KO adenoviral vector hair growth cyst formation hair loss AdV VDR

TLDR Gene therapy with a vitamin D receptor gene improved hair growth in rats with a type of rickets-related baldness.

The study investigated the use of gene therapy to treat alopecia in rats with type II rickets, a hereditary disease caused by a mutation in the vitamin D receptor (VDR) gene. Six 7-week-old female rats with a VDR gene knockout (Vdr-KO) were treated with an adenoviral vector (AdV) expressing the VDR gene. The treated rats showed significant VDR expression in the skin, enhanced hair growth, and low cyst formation, unlike the control groups. This suggests that gene therapy using a VDR-expressing AdV could be a potential treatment for alopecia associated with type II rickets.

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research Functional Analysis of Vitamin D Receptor Using Adenovirus Vector

4 citations, February 2023 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

The study found that certain mutations in the vitamin D receptor can cause rickets and potentially affect hair growth.

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Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

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Gene Therapy for Alopecia in Type II Rickets Model Rats Using Vitamin D Receptor-Expressing Adenovirus Vector