An Induced Pluripotent Stem Cell-Based Approach for Hair Follicle Development and Regeneration

    June 2024 in “ Regenerative Therapy
    Poornima Sivamani, Prakash Gangadaran, Prakash Gangadaran, Byeong‐Cheol Ahn
    TLDR iPSCs show promise for hair regeneration but need more research to improve reliability and effectiveness.
    The review explores the potential of induced pluripotent stem cells (iPSCs) for hair follicle regeneration, emphasizing their ability to differentiate into hair follicle precursor cells and form functional hair follicles. iPSCs, derived from a patient's cells, offer an ethically acceptable and virtually unlimited source for regenerative medicine, reducing the risk of immune rejection. Despite challenges in reliably converting iPSCs into specific hair follicle cells and ensuring consistent hair growth, advancements in differentiation protocols, genome editing, and biomaterial integration show promise. Ongoing clinical trials and future research aim to refine these techniques to enhance the efficacy of iPSC-based hair regeneration therapies.
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