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GlossaryGene Editing

technique to precisely alter an organism's DNA sequence

Gene editing, also known as genome editing, is a technique that allows scientists to alter an organism's DNA with high precision. This process involves adding, removing, or modifying specific genetic material at particular locations in the genome, often using tools like CRISPR-Cas9. It holds potential for treating genetic disorders, improving crop resilience, and even addressing hair loss conditions like alopecia by targeting and correcting the underlying genetic causes.

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research CRISPR/Cas9-Based Targeted Genome Editing for Correction of Recessive Dystrophic Epidermolysis Bullosa Using iPS Cells

1 citations, September 2019 in “Journal of Investigative Dermatology”

The research showed that CRISPR/Cas9 can fix mutations causing a skin disease in stem cells, which then improved skin grafts in mice, but more work on safety and efficiency is needed.

research Development of an Intrinsic Skin Sensor for Blood Glucose Level with CRISPR-Mediated Genome Editing in Epidermal Stem Cells

April 2017 in “Journal of Investigative Dermatology”

Researchers created a skin graft that senses blood glucose and could treat diabetes using CRISPR-edited stem cells.

Recent Advances in Genome-Editing Technology with CRISPR/Cas9 Variants and Stimuli-Responsive Targeting Approaches within Tumor Cells: A Future Perspective of Cancer Management

research Recent Advances in Genome-Editing Technology with CRISPR/Cas9 Variants and Stimuli-Responsive Targeting Approaches within Tumor Cells: A Future Perspective of Cancer Management

1 citations, April 2023 in “International Journal of Molecular Sciences”

New CRISPR/Cas9 variants and nanotechnology-based delivery methods are improving cancer treatment, but choosing the best variant and overcoming certain limitations remain challenges.

Efficient Genome Editing Using CRISPR/Cas9 Ribonucleoprotein Approach in iPS Cells for Recessive Dystrophic Epidermolysis Bullosa

research Efficient Genome Editing Using CRISPR/Cas9 Ribonucleoprotein Approach in iPS Cells for Recessive Dystrophic Epidermolysis Bullosa

April 2019 in “Journal of Investigative Dermatology”

Researchers fixed gene mutations causing a skin disease in stem cells, which then improved skin grafts in mice.

research Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing

60 citations, July 2020 in “ACS Nano”

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

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community I believe CRISPR-on & CRISPR-off is an ultimate CURE for baldness, unlike Hair Cloning or hair loss treatments.

in Research/Science 22 upvotes 3 years ago

The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

in Technology 107 upvotes 1 month ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community How do we only have two treatments to combat hair loss at this point in time?

in Chat 211 upvotes 1 year ago

The post discusses frustration over the limited and not always effective treatments for hair loss, mainly Minoxidil and Finasteride. The conversation includes mentions of potential new treatments like GT20029, HMI-115, CosmeRNA, KX-826, and microneedling, but also highlights the challenges of funding and prioritizing research in this area.

community find a cure for this shit already

in Chat 207 upvotes 4 years ago

Treatments used to prevent and treat male pattern baldness, the difficulty in finding a permanent cure for hair loss, and the potential financial motivations of companies not wanting to find a cure.

community 2 years Fin + Minoxidil Regrowth

in Finasteride/Dutasteride 113 upvotes 4 months ago

A user shared their two-year progress using 2.5mg finasteride daily and minoxidil twice daily, recently adding topical dutasteride. Another user questioned the high finasteride dosage, noting no benefits over 1mg.

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