TLDR Researchers made stem cells from human hair follicle cells with higher efficiency than from skin cells.
Researchers generated induced pluripotent stem (iPS) cells from human hair follicle dermal papilla (DP) cells using lentiviral transfection with Oct4, Sox2, Klf4, and c-Myc, and cultivated them in a medium with valproic acid at 5% oxygen. The reprogramming efficiency of DP cells was 0.03%, higher than the 0.01% efficiency in dermal fibroblasts. This study demonstrated that DP cells could be a viable alternative source for generating iPS cells.
27 citations,
September 2018 in “Nanomedicine: Nanotechnology, Biology and Medicine” Further research is needed to improve hair regeneration using stem cells and nanomaterials.
71 citations,
February 2020 in “Journal of Translational Medicine” Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.
43 citations,
January 2011 in “Plastic and Reconstructive Surgery” Stem cells have great potential for improving wound healing, but more research is needed to find the best types and ways to use them.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Immune cells are essential for early hair and skin development and healing.
29 citations,
December 2019 in “Stem Cells Translational Medicine” Fully regenerating human hair follicles not yet achieved.
77 citations,
April 2016 in “Science Advances” Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.