Characterization of Type II Rickets Model Rats to Reveal Functions of Vitamin D and Vitamin D Receptor

    November 2023 in “ Biomolecules ”
    Yuichiro Iwai, Ayano Iijima, Satoko Kise … Toshiyuki Sakaki
    Studysummary In this study involving genetically modified rats, researchers observed that specific mutations in the vitamin D receptor affect calcium levels and bone formation, emphasizing the receptor's role in maintaining healthy bone density and its importance in regulating hair cycle and skin health.
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    Research cited in this study 10

    1. VDR Is an Essential Regulator of Hair Follicle Regression Through the Progression of Cell Death Life science alliance · 2023
    2. Functional Analysis of Vitamin D Receptor Using Adenovirus Vector Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 2023
    3. Functional Analyses of a Novel Missense and Other Mutations of the Vitamin D Receptor in Association with Alopecia Scientific Reports · 2017
    4. Mutations in the Vitamin D Receptor and Hereditary Vitamin D-Resistant Rickets BoneKEy Reports · 2014
    5. The Role of Vitamin D Receptor Mutations in the Development of Alopecia Molecular and Cellular Endocrinology · 2011
    6. Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor Journal of Biological Chemistry · 2011
    7. Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice Journal of Cellular Physiology · 2010
    8. Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice Endocrine reviews · 2008
    9. Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling Journal of Biological Chemistry · 2003
    10. Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia Endocrinology · 2001