TLDR The research showed that Vitamin D and its receptor are important for healthy bones and normal hair and skin in rats.
The study investigated the role of Vitamin D and Vitamin D Receptor (VDR) in genetically modified (GM) rats, focusing on type II rickets. Two GM rat models were created, one with a VDR(H301Q) mutation and another with a double mutation VDR(R270L/H301Q), both showing almost no affinity for forms of Vitamin D. The study found that these GM rats had significantly lower plasma calcium levels and higher parathyroid hormone and 1,25D3 levels compared to wild-type rats, indicating abnormal bone formation. However, these GM rats did not exhibit symptoms of alopecia or skin cysts, suggesting that unliganded VDR is crucial for maintaining the hair cycle and normal skin. The study concluded that unliganded VDR in keratinocytes is essential for hair cycling and skin homeostasis, while VDR-dependent 1,25D3 action is vital for maintaining plasma calcium levels and normal bone formation.
1 citations,
September 2023 in “Life science alliance” Vitamin D Receptor is crucial for hair follicle shrinkage and cell death, affecting hair growth.
4 citations,
February 2023 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” The study found that certain mutations in the vitamin D receptor can cause rickets and potentially affect hair growth.
107 citations,
March 2014 in “BoneKEy Reports” Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.
37 citations,
April 2011 in “Journal of Biological Chemistry” LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.
53 citations,
May 2010 in “Journal of Cellular Physiology” Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.
1533 citations,
October 2008 in “Endocrine reviews” Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.
119 citations,
July 2016 in “Annals of the New York Academy of Sciences” Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.
6 citations,
November 2021 in “Oncology Research and Treatment” Low Vitamin D receptor levels in breast cancer are linked to worse outcomes and more bone metastases, and could be a marker for prognosis.
107 citations,
March 2014 in “BoneKEy Reports” Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.
22 citations,
November 2016 in “International journal of molecular sciences” Vitamin D receptor is important for regulating hair growth and wound healing in mice.
September 2023 in “Frontiers in medicine” The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.
