Effect of Solvent on Stereoselectivity in Pd/C (Type 39K)-Catalyzed Hydrogenation of Methyl 3-Oxo-4-Aza-5-Androstene-17-Carboxylate, a Key Intermediate for Finasteride and Dutasteride

    July 2007 in “ Organic Process Research & Development ”
    Srihari Babu Karrothu, Naveenkumar Kolla, Amarnath Reddy Lekkala … Rakeshwar Bandichhor
    Studysummary This study optimized the reaction conditions for the stereoselective hydrogenation of a compound used in manufacturing finasteride and dutasteride, improving the selectivity for the desired isomer.
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