Co-Expression of PADI Isoforms During Progenitor Differentiation Enables Functional Diversity

    October 2023 in “ Philosophical Transactions of the Royal Society B Biological Sciences ”
    Kim Vikhe Patil, Mandy Meijer, Kylie Hin-Man Mak … Maria Genander
    Studysummary This study identified novel isoforms of the PADI2 and PADI3 proteins, showing that PADI2β inhibits oligodendrocyte differentiation, possibly by opposing the effect of canonical PADI2, while PADI3β modulates the activity of PADI3α, suggesting new regulatory mechanisms of citrullination in tissue development.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on royalsocietypublishing.org →
    Discuss this study in the Community →

    Research cited in this study 9

    1. Co-Expression of PADI Isoforms During Progenitor Differentiation Enables Functional Diversity Philosophical Transactions of the Royal Society B Biological Sciences · 2023
    2. A Hairy Situation: PADIs in Regeneration and Alopecia Frontiers in Cell and Developmental Biology · 2021
    3. Variant PADI3 in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019
    4. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016
    5. The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008
    6. Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer Journal of biological chemistry/˜The œJournal of biological chemistry · 2007
    7. Peptidylarginine Deiminase Isoforms Are Differentially Expressed in Anagen Hair Follicles and Other Human Skin Appendages Journal of Investigative Dermatology · 2005
    8. Trichohyalin Mechanically Strengthens the Hair Follicle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    9. The Fate of Trichohyalin Journal of biological chemistry/˜The œJournal of biological chemistry · 1997