Co-Expression of PADI Isoforms During Progenitor Differentiation Enables Functional Diversity

October 2023 in “ Philosophical Transactions of the Royal Society B Biological Sciences ”

Kim Vikhe Patil, Mandy Meijer, Kylie Hin-Man Mak, Wei Yang, Ana Mendanha Falcão, Gonçalo Castelo‐Branco, Maria Genander

PADI isoforms PADI3α PADI3β PADI2β PADI2α hair follicles progenitor cell differentiation protein citrullination

TLDR Different PADI isoforms help cells develop diverse functions.

The study investigates the expression and function of PADI isoforms in hair follicles and the oligodendrocyte lineage. It identifies two isoforms, Padi3α and Padi3β, in hair follicles, which increase in expression during progenitor cell differentiation. PADI3α and PADI3β are found in the cytoplasm and can form heterodimers, with PADI3β modulating the activity of PADI3α. Additionally, a new isoform, Padi2β, is discovered in the oligodendrocyte lineage, which inhibits differentiation, contrasting with the known role of PADI2α. This research highlights the diverse roles of PADI isoforms in regulating protein citrullination in complex tissues.

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Research cited in this study

9 / 9 results

research Co-Expression of PADI Isoforms During Progenitor Differentiation Enables Functional Diversity

2 citations , October 2023 in “Philosophical Transactions of the Royal Society B Biological Sciences”

Different PADI isoforms help cells develop diverse functions.

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research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

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Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.

research Peptidylarginine Deiminase Isoforms Are Differentially Expressed in Anagen Hair Follicles and Other Human Skin Appendages

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PAD enzymes play a key role in hair growth and structure.

Co-Expression of PADI Isoforms During Progenitor Differentiation Enables Functional Diversity

Research cited in this study

research Co-Expression of PADI Isoforms During Progenitor Differentiation Enables Functional Diversity

research A Hairy Situation: PADIs in Regeneration and Alopecia

research Variant PADI3 in Central Centrifugal Cicatricial Alopecia

research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

research The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis

research Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer

research Peptidylarginine Deiminase Isoforms Are Differentially Expressed in Anagen Hair Follicles and Other Human Skin Appendages

research Trichohyalin Mechanically Strengthens the Hair Follicle

research The Fate of Trichohyalin

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