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GlossaryPeptidyl Arginine Deiminase Type 2 (PADI2)

enzyme that converts arginine in proteins to citrulline

Peptidyl Arginine Deiminase Type 2 (PADI2) is an enzyme that converts arginine residues in proteins into citrulline, a process known as citrullination. This modification can affect protein function and is involved in various physiological processes, including the regulation of gene expression and the immune response. PADI2 has been implicated in conditions such as rheumatoid arthritis and certain types of alopecia, where abnormal citrullination may play a role in disease pathology.

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research Co-Expression of PADI Isoforms During Progenitor Differentiation Enables Functional Diversity

2 citations , October 2023 in “Philosophical Transactions of the Royal Society B Biological Sciences”

Different PADI isoforms help cells develop diverse functions.

research Distinct Transcriptional Profiles of the Female, Male, and Finasteride-Induced Feminized Male Anogenital Region in Rat Fetuses

10 citations , February 2019 in “Toxicological Sciences”

Finasteride exposure affects gene expression and anogenital distance in male rat fetuses.

research Non-Invasive Human Skin Transcriptome Analysis Using mRNA in Skin Surface Lipids

2 citations , April 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

The conclusion is that analyzing RNA from skin oils is a promising way to understand skin diseases.

research Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles

4 citations , January 2017 in “Biological & pharmaceutical bulletin”

Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.

research Development of Predictive Regression Model for Perceived Hair Breakage in Indian Consumers

1 citations , March 2019 in “International Journal of Cosmetic Science”

The model predicts hair breakage based on key hair properties and helps product developers.

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