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    Glossary PADI3

    enzyme crucial for hair shaft formation and maintenance

    PADI3 stands for Peptidyl Arginine Deiminase, Type III, an enzyme that plays a crucial role in the formation and maintenance of hair. It modifies certain proteins in hair follicles, which is essential for proper hair shaft formation. Mutations in the PADI3 gene can lead to hair disorders such as uncombable hair syndrome, characterized by dry, frizzy hair that is resistant to being combed flat.

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    Research 10 of 113

    1. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016 · 119 citations
    2. Variant <i>PADI3</i> in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019 · 95 citations
    3. Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production Scientific reports · 2020 · 22 citations
    4. A Hairy Cituation – PADIs in Regeneration and Alopecia Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    5. Genetic Susceptibility to Alopecia The New England Journal of Medicine · 2019 · 5 citations
    6. Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles BMC Dermatology · 2020 · 4 citations
    7. Two siblings with uncombable hair syndrome: A new pathogenic variant Pediatric Dermatology · 2024 · 2 citations
    8. Deimination in epidermal barrier and hair formation Philosophical transactions - Royal Society. Biological sciences · 2023 · 2 citations
    9. Co-expression of PADI isoforms during progenitor differentiation enables functional diversity Philosophical Transactions of the Royal Society B Biological Sciences · 2023 · 2 citations
    10. Pili trianguli et canaliculi as a phenotypic subtype in patients with central centrifugal cicatricial alopecia: A scanning electron microscopy study Journal of the American Academy of Dermatology · 2020 · 2 citations
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