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    Glossary PADI3

    enzyme crucial for hair shaft formation and maintenance

    PADI3 stands for Peptidyl Arginine Deiminase, Type III, an enzyme that plays a crucial role in the formation and maintenance of hair. It modifies certain proteins in hair follicles, which is essential for proper hair shaft formation. Mutations in the PADI3 gene can lead to hair disorders such as uncombable hair syndrome, characterized by dry, frizzy hair that is resistant to being combed flat.

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    Research 30 of 113

    1. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016 · 119 citations
    2. Variant <i>PADI3</i> in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019 · 95 citations
    3. Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production Scientific reports · 2020 · 22 citations
    4. A Hairy Cituation – PADIs in Regeneration and Alopecia Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    5. Genetic Susceptibility to Alopecia The New England Journal of Medicine · 2019 · 5 citations
    6. Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles BMC Dermatology · 2020 · 4 citations
    7. Two siblings with uncombable hair syndrome: A new pathogenic variant Pediatric Dermatology · 2024 · 2 citations
    8. Deimination in epidermal barrier and hair formation Philosophical transactions - Royal Society. Biological sciences · 2023 · 2 citations
    9. Co-expression of PADI isoforms during progenitor differentiation enables functional diversity Philosophical Transactions of the Royal Society B Biological Sciences · 2023 · 2 citations
    10. Pili trianguli et canaliculi as a phenotypic subtype in patients with central centrifugal cicatricial alopecia: A scanning electron microscopy study Journal of the American Academy of Dermatology · 2020 · 2 citations
    11. Ugreelig hår Tidsskrift for Den norske legeforening · 2022 · 1 citations
    12. Unravelling the threads of central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2026
    13. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2025
    14. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia. PubMed · 2025
    15. 481 Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2024
    16. Central centrifugal cicatricial alopecia: a subtype of lichen planopilaris in African descent? Portuguese Journal of Dermatology and Venereology · 2024
    17. Support for dermatological research in Sub‐Saharan Africa: insights from African hair and skin research programs International Journal of Dermatology · 2024
    18. This month in JAAD Case Reports: October 2023—Central centrifugal cicatricial alopecia in Black men Journal of the American Academy of Dermatology · 2023
    19. Uncombable hair syndrome due to maternal uniparental disomy of chromosome 1 American journal of medical genetics. Part A · 2022
    20. Uncombable hair syndrome and beyond Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.) · 2022
    21. Central Centrifugal Cicatricial Alopecia (CCCA) CRC Press eBooks · 2021
    22. Deciphering the pathogenesis of central centrifugal cicatricial alopecia 2019
    23. 284 Deciphering the pathogenesis of central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2019
    24. Hair regrowth in a patient with central centrifugal cicatricial alopecia after a 2-month trial of baricitinib JAAD Case Reports · 2023 · 2 citations
    25. Central Centrifugal Cicatricial Alopecia Cutis · 2022 · 3 citations
    26. Central centrifugal cicatricial alopecia The Journal of Family Practice · 2022 · 1 citations
    27. Meta-Analysis of Gene Expression Reveals the Core Transcriptomic Profile of Lesional Scalp in Alopecia Areata Dermatology and Therapy · 2025
    28. Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats PLoS ONE · 2016 · 127 citations
    29. Computational derivation of a molecular framework for hair follicle biology from disease genes Scientific Reports · 2017 · 4 citations
    30. Construction of regulatory network for alopecia areata progression and identification of immune monitoring genes based on multiple machine-learning algorithms Precision clinical medicine · 2023 · 3 citations