The Citrullinating Enzyme PADI4 Governs Progenitor Cell Proliferation and Translation in Developing Hair Follicles

    September 2025 in “ Science Advances ”
    Kim Vikhe Patil, Nil Campamà Sanz, Kylie Hin-Man Mak … Maria Genander
    Studysummary This study reports that PADI4, an enzyme involved in posttranslational protein modifications, regulates progenitor cell transitions in hair follicle development by repressing transcription and interacting with translational and ribosomal processes.
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    Research cited in this study 16

    1. Deep Hair Phenomics: Implications in Endocrinology, Development, and Aging Journal of Investigative Dermatology · 2024
    2. A Hairy Situation: PADIs in Regeneration and Alopecia Frontiers in Cell and Developmental Biology · 2021
    3. Variant PADI3 in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019
    4. Temporal Layering of Signaling Effectors Drives Chromatin Remodeling During Hair Follicle Stem Cell Lineage Progression Cell stem cell · 2018
    5. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016
    6. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    7. Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011
    8. Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    9. Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer Journal of biological chemistry/˜The œJournal of biological chemistry · 2007
    10. Peptidylarginine Deiminase Isoforms Are Differentially Expressed in Anagen Hair Follicles and Other Human Skin Appendages Journal of Investigative Dermatology · 2005
    11. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    12. Trichohyalin Mechanically Strengthens the Hair Follicle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    13. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    14. The Fate of Trichohyalin Journal of biological chemistry/˜The œJournal of biological chemistry · 1997
    15. The Origin of Citrulline-Containing Proteins in the Hair Follicle and the Chemical Nature of Trichohyalin, an Intracellular Precursor Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 1977
    16. Content of Citrulline and Other Amino Acids in Hair Follicle Protein Nature · 1958