Cellular and Molecular Mechanisms of Wound Repair: From Biology to Therapeutic Innovation

    November 2025 in “ Cells
    Caijun Jin, Yongxun Jin, Zhihao Ding, Kong Srey Nuch, Mira Han, Jun-Yeop Shim, Pham Ngoc Chien, Chan Yeong Heo
    TLDR Advancements in wound healing aim to improve personalized treatments and enhance healing outcomes.
    This review explores the cellular and molecular mechanisms involved in wound repair, highlighting the four phases of healing and the roles of various cells and signaling molecules. It discusses how disruptions in these processes can lead to chronic wounds or scarring and examines recent advances in understanding microbial influences, epigenetic regulation, and cellular diversity. The review also evaluates new therapeutic strategies, including biomaterials, engineered scaffolds, and genome-targeted approaches, while addressing challenges such as wound heterogeneity and systemic factors like diabetes and aging. The integration of classical and modern insights aims to advance precision wound medicine and personalized treatments to enhance healing outcomes and quality of life.
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