Hierarchically Assembled Nanofiber Scaffolds With Dual Growth Factor Gradients Promote Skin Wound Healing Through Rapid Cell Recruitment
February 2024
in “
Advanced Science
”
nanofiber scaffold growth factor gradients EGF VEGF extracellular matrix cell proliferation cell migration tissue regeneration wound closure scar formation hair follicle regeneration RNAseq Bioinformatics Analysis Histological Observations Immunohistochemical Staining epidermal growth factor vascular endothelial growth factor
TLDR The new scaffold with two growth factors speeds up skin healing and reduces scarring.
The study developed a 3D hierarchically assembled nanofiber scaffold (RAS) with dual growth factor gradients (EGF and VEGF) to enhance skin wound healing. The RAS mimics the extracellular matrix nanostructures, promoting cell proliferation, migration, and tissue regeneration. The RAS+EGF+VEGF group showed the most significant results, with accelerated wound closure, reduced scar formation, and comparable thickness to normal skin after 14 days. The scaffold also facilitated hair follicle regeneration. The study used RNAseq and Bioinformatics Analysis, Histological Observations, Immunohistochemical Staining, and Statistical Analysis to validate the results. The study suggests that the RAS with dual growth factor gradients could be a promising strategy for skin wound healing.
