Enhancing Diabetic Wound Healing: Advances in Electrospun Scaffolds from Pathogenesis to Therapeutic Applications
February 2024
in “
Frontiers in bioengineering and biotechnology
”
Studysummary This research review outlines the challenges of diabetic wounds, such as diabetic foot ulcers, and examines the potential of electrospinning nanofiber scaffolds to improve healing by promoting tissue formation, allowing drug release, and enhancing specific wound healing properties.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Diabetic wounds, particularly diabetic foot ulcers (DFUs), are chronic and severe, often leading to hospitalization, amputation, or mortality, and pose a significant economic burden. Electrospun scaffolds, which mimic the extracellular matrix, promote fibroblast activity and new skin tissue formation, making them promising for diabetic wound treatment. These scaffolds can be tailored for controlled drug release and modified for specific functionalities, enhancing their therapeutic potential. The article reviews the pathological mechanisms of diabetic wounds, the benefits of electrospun nanofiber scaffolds, and various studies on their use and drug loading methods, highlighting their potential to improve diabetic wound healing.
