Current Application of Tissue-Engineered Dermal Scaffolds Mimicking the Extracellular Matrix Microenvironment in Wound Healing

January 2025 in “ Regenerative Therapy ”

Xinran Ding, Sujie Xie, Wei Zhang, Yushu Zhu, Dayuan Xu, Shuyuan Xian, Hanlin Sun, Xinya Guo, Yixu Li, Jianyu Lu, Xirui Tong, Runzhi Huang, Shizhao Ji, Zhaofan Xia

tissue-engineered dermal scaffolds extracellular matrix angiogenesis growth factors cell attachment cell migration cell proliferation extracellular matrix deposition

TLDR Tissue-engineered scaffolds help heal difficult wounds by supporting cell growth and repair.

This review discusses the advancements in tissue-engineered dermal scaffolds that mimic the extracellular matrix (ECM) microenvironment to enhance wound healing. These scaffolds are designed to support cell proliferation, differentiation, and migration, using ECM-derived molecules like collagen and fibrin. The integration of growth factors and cells, such as fibroblasts and mesenchymal stem cells, enhances scaffold efficacy by promoting angiogenesis and tissue regeneration. Despite promising results in animal models, challenges remain in clinical translation, particularly in customizing scaffolds to meet specific wound requirements, such as mechanical strength for burns or pro-angiogenic properties for chronic ulcers. Further research is needed to optimize scaffold modifications for improved skin regeneration and clinical application.

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