Current Application of Tissue-Engineered Dermal Scaffolds Mimicking the Extracellular Matrix Microenvironment in Wound Healing

January 2025 in “ Regenerative Therapy ”

Xinran Ding, Sujie Xie, Wei Zhang, Yushu Zhu, Dayuan Xu, Shuyuan Xian, Hanlin Sun, Xinya Guo, Yixu Li, Jianyu Lu, Xirui Tong, Runzhi Huang, Shizhao Ji, Zhaofan Xia

tissue-engineered dermal scaffolds extracellular matrix angiogenesis growth factors cell attachment cell migration cell proliferation extracellular matrix deposition

Studysummary This review highlights the potential of bioengineered dermal scaffolds in tissue engineering to enhance wound healing by mimicking the dermal structure and supporting cellular processes, while also discussing recent advancements and challenges in scaffold technology.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This review discusses the advancements in tissue-engineered dermal scaffolds that mimic the extracellular matrix (ECM) microenvironment to enhance wound healing. These scaffolds are designed to support cell proliferation, differentiation, and migration, using ECM-derived molecules like collagen and fibrin. The integration of growth factors and cells, such as fibroblasts and mesenchymal stem cells, enhances scaffold efficacy by promoting angiogenesis and tissue regeneration. Despite promising results in animal models, challenges remain in clinical translation, particularly in customizing scaffolds to meet specific wound requirements, such as mechanical strength for burns or pro-angiogenic properties for chronic ulcers. Further research is needed to optimize scaffold modifications for improved skin regeneration and clinical application.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research Investigation of Human Hair Keratin-Based Nanofibrous Scaffold for Skin Tissue Engineering Application

August 2023 in “Drug Delivery and Translational Research”

Human hair keratin was used to create a scaffold that could help with skin repair.

research Hopes and Limits of Adipose-Derived Stem Cells and Mesenchymal Stem Cells in Wound Healing

263 citations , February 2020 in “International journal of molecular sciences”

This paper discusses the potential roles of adipose tissue derived stem cells in skin regeneration and wound healing but emphasizes the need for further research on their effectiveness in clinical settings.

research Immunological Challenges Associated With Artificial Skin Grafts: Available Solutions and Stem Cells in Future Design of Synthetic Skin

105 citations , December 2017 in “Journal of Biological Engineering”

This review discusses the challenges of skin graft acceptance and examines current strategies and alternatives for full-thickness skin replacement and repair, noting that immunological rejection remains a significant hurdle.

research Collagen and Fractionated Platelet-Rich Plasma Scaffold for Dermal Regeneration

42 citations , April 2016 in “Plastic and reconstructive surgery/PSEF CD journals”

This study found that hydrogels supplemented with fractionated platelet-rich plasma recruited more dermal-derived stem cells and accelerated healing, leading to hair growth and skin regeneration in rats.

research Human Wharton’s Jelly Mesenchymal Stem Cells Plasticity Augments Scar-Free Skin Wound Healing with Hair Growth

102 citations , April 2014 in “PloS one”

In this study, Wharton’s Jelly Mesenchymal Stem Cells, cultured with human platelet lysate, showed enhanced wound-healing capabilities and multilineage differentiation potential, distinguishing them from bone marrow-derived stem cells and presenting exciting prospects for regenerative medicine.