Current Application of Tissue-Engineered Dermal Scaffolds Mimicking the Extracellular Matrix Microenvironment in Wound Healing

January 2025 in “ Regenerative Therapy ”

Xinran Ding, Sujie Xie, Wei Zhang, Yushu Zhu, Dayuan Xu, Shuyuan Xian, Hanlin Sun, Xinya Guo, Yixu Li, Jianyu Lu, Xirui Tong, Runzhi Huang, Shizhao Ji, Zhaofan Xia

tissue-engineered dermal scaffolds extracellular matrix angiogenesis growth factors cell attachment cell migration cell proliferation extracellular matrix deposition

TLDR Tissue-engineered scaffolds help heal difficult wounds by supporting cell growth and repair.

Tissue-engineered dermal scaffolds, which mimic the extracellular matrix, are emerging as promising solutions for complex or non-healing wounds by providing a structural framework that supports cell attachment, migration, and proliferation. These scaffolds, made from natural or synthetic materials, can be combined with cells or growth factors to enhance angiogenesis, extracellular matrix deposition, and functional recovery. The review highlights recent advancements in cell- and growth factor-modified scaffolds and discusses the challenges and future directions for their clinical application in wound healing.

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