Collagen and Fractionated Platelet-Rich Plasma Scaffold for Dermal Regeneration

April 2016 in “ Plastic and reconstructive surgery/PSEF CD journals ”

Matthew T. Houdek, Cody C. Wyles, Paul G. Stalboerger, André Terzic, Atta Behfar, Steven L. Moran

collagen fractionated platelet-rich plasma PRP dermal regeneration hydrogel scaffold type I collagen fetal bovine serum dermal-derived stem cells wound healing angiogenesis hair formation sweat glands skin regeneration stem cells blood vessel formation hair growth

TLDR The hydrogel with fractionated PRP improves skin regeneration by enhancing wound healing and growth of skin structures.

The study aimed to develop a scaffold for dermal regeneration that could recruit dermal stem cells from adjacent tissue without pre-seeding. Researchers created a hydrogel scaffold using type I collagen and fractionated platelet-rich plasma (PRP) and compared it to a control hydrogel with type I collagen and fetal bovine serum. The PRP-supplemented scaffolds showed increased recruitment of dermal-derived stem cells and enhanced wound healing, angiogenesis, and formation of hair and sweat glands compared to the control. This novel approach demonstrated potential for regenerating skin and treating large defects.

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Research cited in this study

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Collagen and Fractionated Platelet-Rich Plasma Scaffold for Dermal Regeneration

Research cited in this study

research Promotional Effect of Platelet-Rich Plasma on Hair Follicle Reconstitution In Vivo

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

research Human Skin Stem Cells and the Aging Process

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