Collagen and Fractionated Platelet-Rich Plasma Scaffold for Dermal Regeneration
May 2016
in “
Plastic and reconstructive surgery/PSEF CD journals
”
TLDR The hydrogel with fractionated PRP improves skin regeneration by enhancing wound healing and growth of skin structures.
The study aimed to develop a scaffold for dermal regeneration that could recruit dermal stem cells from adjacent tissue without pre-seeding. Researchers created a hydrogel scaffold using type I collagen and fractionated platelet-rich plasma (PRP) and compared it to a control hydrogel with type I collagen and fetal bovine serum. The PRP-supplemented scaffolds showed increased recruitment of dermal-derived stem cells and enhanced wound healing, angiogenesis, and formation of hair and sweat glands compared to the control. This novel approach demonstrated potential for regenerating skin and treating large defects.
