TLDR The hydrogel with fractionated PRP improves skin regeneration by enhancing wound healing and growth of skin structures.
The study aimed to develop a scaffold for dermal regeneration that could recruit dermal stem cells from adjacent tissue without pre-seeding. Researchers created a hydrogel scaffold using type I collagen and fractionated platelet-rich plasma (PRP) and compared it to a control hydrogel with type I collagen and fetal bovine serum. The PRP-supplemented scaffolds showed increased recruitment of dermal-derived stem cells and enhanced wound healing, angiogenesis, and formation of hair and sweat glands compared to the control. This novel approach demonstrated potential for regenerating skin and treating large defects.
63 citations,
October 2013 in “Dermatologic Surgery” Platelet-Rich Plasma (PRP) increases the number of new hair follicles and speeds up hair formation.
270 citations,
March 2012 in “Dermatologic Surgery” Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.
143 citations,
September 2008 in “Experimental gerontology” Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.
251 citations,
October 2006 in “Plastic and reconstructive surgery/PSEF CD journals” Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.
20 citations,
October 2018 in “Aesthetic Plastic Surgery” PRP shows promise for improving facial wrinkles, skin elasticity, and hair growth, but more research is needed to standardize its use and understand its effects.
20 citations,
February 2017 in “International Journal of Dermatology” Platelet-based therapies using a patient's own blood show promise for skin and hair regeneration but require more research for confirmation.
35 citations,
January 2020 in “Skin Pharmacology and Physiology” The review concluded that keeping the hair-growing ability of human dermal papilla cells is key for hair development and growth.
April 2024 in “International journal of molecular sciences” Combination pharmacotherapy is generally more effective for treating keloids and hypertrophic scars.
August 2024 in “Stem Cell Research & Therapy” New regenerative therapies show promise for treating hair loss.
