Human Wharton’s Jelly Mesenchymal Stem Cells Plasticity Augments Scar-Free Skin Wound Healing with Hair Growth

    April 2014 in “ PloS one ”
    Vikram Sabapathy, Balasubramanian Sundaram, Sreelakshmi Vm, Pratheesh Mankuzhy, Sanjay Kumar
    TLDR Wharton’s Jelly stem cells from the umbilical cord improve skin healing and hair growth without scarring.
    The study demonstrated that human Wharton’s Jelly Mesenchymal Stem Cells (WJ-MSCs) significantly enhanced scar-free skin wound healing and promoted hair growth in a SCID mice model. WJ-MSCs maintained their phenotypic attributes and multilineage differentiation capacity, showing higher immunomodulatory potential compared to adult bone marrow-derived MSCs. When combined with a decellularized amniotic membrane scaffold, WJ-MSCs significantly improved wound healing, reduced scar formation, and promoted hair growth. The study highlighted the potential of WJ-MSCs for regenerative medical applications, particularly in improving wound healing and hair growth, supported by various histopathological evaluations and molecular analyses.
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