New Insights Into Balancing Wound Healing And Scarless Skin Repair

January 2023 in “ Journal of Tissue Engineering ”

Shengxi Zhou, Mengbo Xie, Jingjing Su, Bingjie Cai, Jingan Li, Kun Zhang

TLDR Scarless skin repair is possible by understanding and balancing wound healing mechanisms.

The document reviewed the complex mechanisms of wound healing and scar formation, emphasizing the interaction of various cells, cytokines, and mechanical forces. It highlighted the significant expansion in research on scar-free wound repair, focusing on understanding these mechanisms to develop effective treatments. The paper also discussed different types of wounds, the process of scar formation, and current research progress on balancing wound healing with scar prevention, offering strategies for achieving scarless skin repair.

View this study on journals.sagepub.com →

Discuss this study in the Community →

Research cited in this study

18 / 18 results

research Application of Hydrogels as Three-Dimensional Bioprinting Ink for Tissue Engineering

49 citations , January 2023 in “Gels”

Hydrogels are crucial for 3D bioprinting in tissue engineering.

research Gene Therapy to Enhance Angiogenesis in Chronic Wounds

36 citations , August 2022 in “Molecular Therapy — Nucleic Acids”

Gene therapy shows promise for healing chronic wounds but needs more research to overcome challenges.

research Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing

81 citations , March 2022 in “Frontiers in Bioengineering and Biotechnology”

Bioengineered scaffolds help heal skin wounds, but perfect treatments are still needed.

research Fibroblasts in Scar Formation: Biology and Clinical Translation

18 citations , January 2022 in “Oxidative Medicine and Cellular Longevity”

Fibroblasts are crucial in scar formation and wound healing, with potential therapies aiming for scarless healing.

research Mechanical and Immunological Regulation in Wound Healing and Skin Reconstruction

54 citations , May 2021 in “International Journal of Molecular Sciences”

Advances in mechanobiology and immunology could lead to scarless wound healing.

research Wound Healing: Cellular Mechanisms and Pathological Outcomes

1425 citations , September 2020 in “Open Biology”

Better understanding of wound healing is needed to develop effective treatments for chronic wounds.

research Recent Advances in the Controlled Release of Growth Factors and Cytokines for Improving Cutaneous Wound Healing

88 citations , July 2020 in “Frontiers in Cell and Developmental Biology”

Bioengineered materials improve wound healing by releasing growth factors and cytokines more effectively than traditional methods.

research Cutaneous Wound Healing: Canine Allogeneic ASC Therapy

20 citations , June 2020 in “Stem Cell Research & Therapy”

Using stem cells from fat tissue can significantly improve wound healing in dogs.

Bio-Multifunctional Alginate/Chitosan/Fucoidan Sponges with Enhanced Angiogenesis and Hair Follicle Regeneration for Promoting Full-Thickness Wound Healing

research Bio-Multifunctional Alginate/Chitosan/Fucoidan Sponges with Enhanced Angiogenesis and Hair Follicle Regeneration for Promoting Full-Thickness Wound Healing

83 citations , June 2020 in “Materials & Design”

Sponge helps heal wounds faster with less inflammation and better skin/hair growth.

research Nanotechnology Approaches in Chronic Wound Healing

110 citations , April 2020 in “Advances in Wound Care”

Nanotechnology shows promise for better chronic wound healing but needs more research.

research Epidermal Stem Cells in Wound Healing and Their Clinical Applications

129 citations , July 2019 in “Stem Cell Research & Therapy”

Epidermal stem cells help heal severe skin wounds and have potential for medical treatments.

research Toward Understanding Scarless Skin Wound Healing and Pathological Scarring

113 citations , June 2019 in “F1000Research”

Scarless healing is complex and influenced by genetics and environment, while better understanding could improve scar treatment.

research Stem Cell Dynamics, Migration, and Plasticity During Wound Healing

211 citations , November 2018 in “Nature Cell Biology”

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

research Wound Healing: A Cellular Perspective

1160 citations , November 2018 in “Physiological Reviews”

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

research Production-Scale Fibronectin Nanofibers Promote Wound Closure and Tissue Repair in a Dermal Mouse Model

68 citations , March 2018 in “Biomaterials”

Large-scale fibronectin nanofibers help heal wounds and repair tissue in a skin model of a mouse.

research Scarless Wound Healing: Transitioning from Fetal Research to Regenerative Healing

79 citations , January 2018 in “Wiley Interdisciplinary Reviews-Developmental Biology”

Understanding how baby skin heals without scars could help develop treatments for adults to heal wounds without leaving scars.

Sericin Hydrogels Promote Skin Wound Healing with Effective Regeneration of Hair Follicles and Sebaceous Glands After Complete Loss of Epidermis and Dermis

research Sericin Hydrogels Promote Skin Wound Healing with Effective Regeneration of Hair Follicles and Sebaceous Glands After Complete Loss of Epidermis and Dermis

84 citations , January 2018 in “Biomaterials Science”

Sericin hydrogels heal skin wounds well, regrowing hair and glands with less scarring.

research Pro-Regenerative Hydrogel Restores Scarless Skin During Cutaneous Wound Healing

41 citations , September 2017 in “Advanced Healthcare Materials”

A special hydrogel helps heal skin without scars and regrows hair.