Deep Hair Phenomics: Implications in Endocrinology, Development, and Aging

    September 2024 in “ Journal of Investigative Dermatology ”
    Jasson Makkar, Jorge Flores, Mason Matich … Ryan R. Driskell
    Studysummary This study developed a deep learning-based tool to quantify individual hair fibers in mice, revealing distinct hair phenotypes linked to hormonal, genetic, and age-related factors, and suggesting its potential for new diagnostic methods through hair analysis.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on secure.jbs.elsevierhealth.com →
    Discuss this study in the Community →

    Research cited in this study 37

    1. The Use of 2D:4D Digit Ratio as a Predictor of Androgenetic Alopecia: A Review Dermatology practical & conceptual · 2023
    2. Mechanical Stimulation of Human Hair Follicle Outer Root Sheath Cultures Activates Adjacent Sensory Neurons Science advances · 2023
    3. Cyclical Dermal Micro-Niche Switching Governs the Morphological Infradian Rhythm of Mouse Zigzag Hair Nature Communications · 2023
    4. A Machine Learning Algorithm Applied to Trichoscopy for Androgenic Alopecia Staging and Severity Assessment Dermatology practical & conceptual · 2023
    5. Human Scalp Hair as a Thermoregulatory Adaptation Proceedings of the National Academy of Sciences · 2023
    6. Effects of Hormones and Endocrine Disorders on Hair Growth Cureus · 2022
    7. An Overview of the Genetic Aspects of Hair Loss and Its Connection with Nutrition PubMed · 2022
    8. Deep Learning-Based Trichoscopic Image Analysis and Quantitative Model for Predicting Basic and Specific Classification in Male Androgenetic Alopecia Acta dermato-venereologica · 2021
    9. Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging Journal of Investigative Dermatology · 2020
    10. Stigmatization Caused by Hair Loss – A Systematic Literature Review Journal der Deutschen Dermatologischen Gesellschaft · 2020
    11. Hormonal Effects on Hair Follicles International journal of molecular sciences · 2020
    12. Male Pattern Baldness and Risk of Incident Skin Cancer in a Cohort of Men International Journal of Cancer · 2016
    13. Stress And The Hair Growth Cycle: Cortisol-Induced Hair Growth Disruption PubMed · 2016
    14. The Diagnosis and Treatment of Hair and Scalp Diseases Deutsches Arzteblatt International · 2016
    15. Systemic Causes of Hair Loss Annals of Medicine · 2016
    16. Prediction of Male-Pattern Baldness from Genotypes European Journal of Human Genetics · 2015
    17. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    18. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    19. Perivascular Hair Follicle Stem Cells Associate With a Venule Annulus Journal of Investigative Dermatology · 2013
    20. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    21. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    22. Epidermal Patterning and Induction of Different Hair Types During Mouse Embryonic Development Birth defects research · 2009
    23. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    24. Mice Expressing a Mutant KRT75 (K6hf) Allele Develop Hair and Nail Defects Resembling Pachyonychia Congenita Journal of Investigative Dermatology · 2007
    25. Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes Proceedings of the National Academy of Sciences of the United States of America · 2006
    26. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    27. Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling Proceedings of the National Academy of Sciences of the United States of America · 2005
    28. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    29. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    30. Overexpression Of Sonic Hedgehog Suppresses Embryonic Hair Follicle Morphogenesis Developmental Biology · 2003
    31. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    32. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    33. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    34. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    35. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    36. Keratinocyte Growth Factor Is an Important Endogenous Mediator of Hair Follicle Growth, Development, and Differentiation. Normalization of the Nu/Nu Follicular Differentiation Defect and Amelioration of Chemotherapy-Induced Alopecia. PubMed · 1995
    37. Hair Anatomy for the Clinician Journal of The American Academy of Dermatology · 1991

    Related research 2

    1. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    2. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001