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      The Genetics of Acne

      research The Genetics of Acne

      July 2025 in “Annals of Human Genetics”
      This review examines the genetics of acne vulgaris, concluding that stem/progenitor cell maintenance and cellular migration are key processes in its pathogenesis, potentially shifting future treatment strategies beyond traditional antibiotics and retinoids, which have notable side effects.

      research Genetic Analysis of Androgen Receptors in Development and Disease

      44 citations , January 1999 in “Advances in pharmacology”
      This chapter reviews recent findings on androgen receptor function, structure, and interactions, highlighting post-translational modifications and mutations related to prostate cancer, but reports no new experimental results.
      Genetic Susceptibility to Alopecia

      research Genetic Susceptibility to Alopecia

      5 citations , February 2019 in “The New England Journal of Medicine”
      This article discusses the composition and function of the dermal papilla in hair follicles, focusing on its role in hair shaft generation and suggesting that cell loss in this area may contribute to hair loss.

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      community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

       112 upvotes 1 year ago
      CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

      community A man in his 80s with full head of hair.

       473 upvotes 4 months ago
      Genetics play a major role in hair loss, with some people keeping a full head of hair into old age without using treatments like minoxidil or finasteride. Many express frustration over their own hair loss and the perceived unfairness of genetic differences.

      community Sugar and Hair loss connections

      in Research/Science  41 upvotes 1 year ago
      High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

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