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Glossary Genetic Disorders

conditions caused by DNA abnormalities, often inherited from parents

Genetic disorders, also known as hereditary disorders or genetic diseases, are conditions caused by abnormalities in an individual's DNA. These abnormalities can be due to mutations in a single gene, multiple genes, or chromosomal changes, and they can be inherited from one or both parents. Examples include cystic fibrosis, sickle cell anemia, and Down syndrome.

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Research

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research Genetic Disorders and Defects in Vitamin D Action

151 citations , June 2010 in “Endocrinology and metabolism clinics of North America”

This article compares two rare genetic diseases, vitamin D-dependent rickets type 1 and type 2, focusing on their similar presentations of hypocalcemia and rickets in infancy, but reports no new clinical results.

research Genetic disorders of keratin: are scarring alopecias a sub-set?

14 citations , July 1994 in “Journal of Dermatological Science”

In this study, transgenic mice expressing a mutant K6 gene developed progressive scarring alopecia and keratosis, suggesting they may model a new keratin disorder.

research Molecular Genetics of Keratinization Disorders – What’s New About Ichthyosis

18 citations , January 2020 in “Acta dermato-venereologica”

This overview discusses advancements in the understanding of molecular genetics in heritable keratinization disorders, focusing on recent cases of inherited ichthyosis, and reports no new clinical results.

research Genetic Basis of Pigmentation and Its Disorders

7 citations , December 1981 in “International Journal of Dermatology”

Understanding genes can help diagnose and treat skin color disorders.

research To grow or not to grow: Hair morphogenesis and human genetic hair disorders

43 citations , December 2013 in “Seminars in Cell & Developmental Biology”

This mini-review discusses human hair follicle development and summarizes genetic disorders linked to abnormalities in hair follicle morphogenesis, structure, or regeneration, but reports no new experimental results.

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Community Join

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community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community DUPA, Non Responders and Connective Tissue Disorders

8 upvotes 1 year ago

A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.

community Female diffuse hair loss on spiro with irregular periods (photos) + genetic hair loss

in Female 16 upvotes 2 years ago

A 34-year-old woman is experiencing diffuse hair loss and irregular periods, possibly due to long-term spironolactone use. She is considering minoxidil and finasteride for treatment and seeking medical advice for androgenic alopecia and hormonal imbalances.

community Do we know exactly why some people respond so great to dut/fin,min and others dont?

in Research/Science 29 upvotes 1 year ago

Genetic factors, enzyme activity, and DHT sensitivity affect individual responses to hair loss treatments like finasteride, minoxidil, and dutasteride. Starting treatments early can slow hair loss, but results vary among individuals.

community My Honest Take on PFS and Effective Treatment.

6 upvotes 5 days ago

Finasteride may trigger anxiety disorders in susceptible individuals, leading to symptoms often mistaken for permanent damage. Effective treatment should focus on addressing anxiety and panic disorders rather than hormonal imbalances.

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Learn

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learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Dutasteride

A stronger DHT blocker than finasteride, approved for hair loss only in South Korea and Japan and off-label elsewhere, with the same class of side effects and a much longer washout.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

learn Vitamin B1

Thinning hair over time? It might not just be genetics: lack of B1 and B2 could be silently working against you. There is no verified human trial showing that B1 or B2 deficiency causes thinning hair or that correcting it regrows hair; a 2019 review concludes the role of micronutrients in hair loss is real but unclear and still needs controlled trials.

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Clinics

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Trichology
The Pharmacy for Hair Loss & Scalp Disorders, PLLC.Brentwood, TN · US

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