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GlossaryGenetic Disorders

conditions caused by DNA abnormalities, often inherited from parents

Genetic disorders, also known as hereditary disorders or genetic diseases, are conditions caused by abnormalities in an individual's DNA. These abnormalities can be due to mutations in a single gene, multiple genes, or chromosomal changes, and they can be inherited from one or both parents. Examples include cystic fibrosis, sickle cell anemia, and Down syndrome.

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community Kintor has announced the results for their human Phase I trials of GT20029

in Research/Science 253 upvotes 2 years ago

The conversation discusses the potential of a new hair loss treatment, GT20029, which may prevent hair loss by destroying androgen receptors on the scalp. Users express hope for the treatment's success and speculate on its usage routine, effectiveness, and possible side effects.

community Early signs that tell you you have Male Pattern Baldness

in Finasteride/Dutasteride 154 upvotes 3 years ago

Male Pattern Baldness, and identifying early signs of it. The treatments discussed to combat and slow balding include finasteride, dutasteride and minoxidil.

community CRISPR treatment for AGA on the horizon after approval for blood disorders

in Treatment 10 upvotes 10 months ago

CRISPR treatments for blood disorders have been approved, leading to discussions about its potential for treating hair loss (AGA). A study showed that editing a gene related to DHT sensitivity could lead to hair regrowth, suggesting CRISPR may eventually be used for AGA, but it's expected to be expensive and not soon available.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community How does hair loss and recovery work?

in Chat 12 upvotes 3 months ago

Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

community Keratin microspheres - breakthrough

in Research/Science 13 upvotes 9 months ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

in Finasteride/Dutasteride 191 upvotes 2 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community Totally confused by doctors opinions, would appreciate some clarity

in Treatment 1 upvotes 2 weeks ago

The user is experiencing hair loss and confusion over conflicting medical advice, with treatments including minoxidil, finasteride, and topical corticosteroids. They are unsure about the necessity of a biopsy and the timing of using minoxidil, while also considering the impact of potential androgenetic alopecia and telogen effluvium.

community Maintaining hair until Breezula without Fin

in Treatment 6 upvotes 4 years ago

A 21-year-old male experienced side effects from topical finasteride and is seeking alternative treatments to maintain hair until Breezula is available. He is considering using minoxidil, Nizoral, micro-needling, and vitamin D supplementation, and may try CB or RU58841 if necessary.

community Bryan (the guy who reversed aging) shares treatment that reversed his hair loss

in Treatment 1073 upvotes 1 month ago

A person improved hair loss from Norwood 3 to Norwood 2 using a topical formula with minoxidil, dutasteride, and tretinoin, plus oral minoxidil and red light therapy. There is skepticism about the treatment's effectiveness and concerns about misleading comparison photos.

community Dental technician is convinced that he has found the cause of pattern hair loss

in Research/Science 317 upvotes 4 months ago

A dental technician claims malocclusion causes pattern hair loss due to poor scalp circulation. Users debate this, noting treatments like finasteride, minoxidil, and microneedling focus on DHT and blood flow.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community 8-months progress: dermarolling + supplements

in Progress Pictures 258 upvotes 7 months ago

A user shared an 8-month hair loss treatment progress using daily saw palmetto and biotin capsules, weekly dermarolling, and a scalp lotion mix of castor, jojoba, and rosemary oils, avoiding finasteride and minoxidil due to side effects and cost. The user reported encouraging progress with slight hairline improvement and better crown area, attributing most success to dermarolling.

community Let's talk about natural options and last resorts.

in Chat 7 upvotes 7 months ago

The user discusses their long struggle with hair loss, considering various treatments like hair transplants, hair systems, and natural methods such as micro-needling, vitamin supplements, and a healthy lifestyle. They express concerns about side effects from drugs like finasteride and ultimately lean towards using a hair system for better appearance and confidence.

community Diffuse thinning is so brutal.

in Styling 72 upvotes 1 year ago

A 25-year-old with AGA experienced hair thinning and dandruff, stabilized with topical finasteride and minoxidil but saw minimal regrowth. They seek advice on styling and consider oral minoxidil and microneedling for denser hair.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 97 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Wtf have we been doing for the last 30 years

in Treatment 511 upvotes 2 days ago

Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

community People's ignorance on MPB is both frustrating and harmful to balding men and it's important to educate other balding men on Fin/Min/Dut (Discussion)

in Finasteride/Dutasteride 154 upvotes 1 week ago

Many are unaware of effective male pattern baldness treatments like finasteride and minoxidil, often opting for ineffective remedies. Educating others on proven treatments and potential side effects is crucial.

community Does vitamin D deficiency actually cause hair loss? Has anyone actually grew back hair after fixing vitamin d levels?

in Chat 65 upvotes 2 months ago

Vitamin D deficiency can contribute to hair loss, but it is not the sole cause, and supplementation may not always resolve the issue. Treatments like finasteride and minoxidil are recommended for hair regrowth, with vitamin D and other supplements providing additional support.

community Why a lot of people seems to hate on topical fin even though it suppresses more scalp dht?

in Chat 20 upvotes 2 months ago

Topical finasteride may reduce more scalp DHT but is seen as inconsistent and messy compared to oral finasteride. Users report mixed results with both forms, with some preferring oral for its convenience and consistent dosing, while others find topical effective but harder to apply.

community Why balding gets worse in every generation?

in Chat 81 upvotes 5 months ago

Balding seems to worsen with each generation, possibly due to stress, diet, and environmental factors. The user started treatments like Minoxidil and finasteride.

community So does oral minoxidil age your skin or not

in Minoxidil 41 upvotes 8 months ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 9 months ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community Just had this wild thought come into my head.

in Satire 403 upvotes 9 months ago

The conversation is about the debate over the existence of Post-Finasteride Syndrome (PFS) and its symptoms, with some users skeptical about PFS and others discussing side effects like erectile dysfunction and gynecomastia from hair loss treatments like finasteride. Specific treatments mentioned include finasteride, viagra, and a joke about using a popsicle stick for erectile support.

community How uninformed the general public is about hair loss

in Chat 318 upvotes 10 months ago

The conversation highlights the general public's lack of knowledge about hair loss, with various ineffective remedies suggested, such as not wearing hats or using hair fibers. The only effective treatments mentioned for male pattern baldness are medications like minoxidil and finasteride, and hair transplants.

community Anyone else not have hobbies anymore because of this?

in Chat 117 upvotes 1 year ago

The user is expressing an obsession with hair loss and spends all their time researching and discussing it. Other users suggest seeking therapy and focusing on other aspects of life.

community In my opinion baldness is more prevalent now and it's being ignored..

in Chat 236 upvotes 1 year ago

The conversation is about the prevalence of baldness among young men and the potential factors contributing to it. Specific treatments mentioned include minoxidil and finasteride.

community 137 years old and still far more hair than the average r/tressless user

in Satire 1067 upvotes 1 year ago

The post and conversation are about a user claiming to be 137 years old with a full head of hair. Specific treatments mentioned include dutasteride, RU58841, and minoxidil.

community I find it funny a bunch of us on here are on drugs for hairloss and maintain clean/healthy lives and then there’s these mf’s in the 90’s juiced to the gills with steroids and have better hair than all of us lol

in Satire 353 upvotes 1 year ago

The conversation is about the effects of steroids on hair loss. Some users believe that steroids can cause hair loss, while others argue that it depends on individual sensitivity to DHT. There is also discussion about the appearance of balding individuals who use steroids.