Ca2+ Mediated Protein Citrullination Regulates Proliferation in the Regenerating and Malignant CNS

    January 2026
    Samuel H. Crossman, Thamodi Walpola, Alon M. Douek … Jan Kaslin
    Studysummary This study found that Ca²⁺ signaling and peptidylarginine deiminase enzymes play a crucial role in activating neural stem cells in response to injury in zebrafish, suggesting potential therapeutic targets for CNS injuries and cancer.
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    Research cited in this study 3

    1. Hallmarks of Regeneration Cell stem cell · 2024
    2. Noncoding dsRNA Induces Retinoic Acid Synthesis to Stimulate Hair Follicle Regeneration via TLR3 Nature Communications · 2019
    3. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015