The Investigation of Minoxidil-Induced Ca2+ Rises and Non-Ca2+-Triggered Cell Death in PC3 Human Prostate Cancer Cells

June 2016 in “ Journal of receptor and signal transduction research ”

I-Shu Chen, Chiang-Ting Chou, Yuan-Yuarn Liu, Chia‐Cheng Yu, Wei Liang, Chun-Chi Kuo, Pochuen Shieh, Daih‐Huang Kuo, Fu‐An Chen, Chung‐Ren Jan

minoxidil intracellular calcium cell death Rogaine

TLDR Minoxidil increases calcium levels and kills prostate cancer cells independently of calcium.

The study investigated the effects of minoxidil on intracellular calcium levels ([Ca²⁺]i) and cell death in PC3 human prostate cancer cells. The researchers found that minoxidil induced a rise in [Ca²⁺]i, which was associated with cell death. However, they also observed that minoxidil could trigger cell death through mechanisms that did not involve changes in [Ca²⁺]i. These findings suggested that minoxidil might have potential therapeutic effects beyond its known use for hair growth, particularly in the context of prostate cancer treatment.

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Research cited in this study

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research Emerging Treatments in Alopecia

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research Minoxidil May Suppress Androgen Receptor-Related Functions

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research Minoxidil Use in Dermatology, Side Effects, and Recent Patents

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Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

research Rapid Determination of Minoxidil in Human Plasma Using Ion-Pair HPLC

20 citations, October 2004 in “Journal of Pharmaceutical and Biomedical Analysis”

Quick method to measure minoxidil in blood, accurate and useful for labs.

research Minoxidil: Inhibition of Proliferation of Keratinocytes In Vitro

14 citations, September 1991 in “Journal of Investigative Dermatology”

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research Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil

63 citations, September 1987 in “Journal of Biological Chemistry”

Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.

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