Sequencing KRT71 as a Candidate Gene for Hair Shape Variation in Dromedary Camels

January 2025 in “ Kuwait Journal of Science ”

Kawther M. Akbar, Bader H. Alhajeri, Hasan Alhaddad

Keratin 71 KRT71 polymorphisms genetic basis hair shape variation

TLDR KRT71 gene variants may influence camel hair shape but don't fully explain it.

This study sequenced the KRT71 gene in 102 dromedary camels to investigate genetic polymorphisms that might explain hair shape variations, identifying several SNPs, including a potentially damaging one affecting protein structure. While certain alleles and genotypes were more frequent in specific camel types and hair shape categories, no definitive association with hair shape was found, indicating that other genes might influence hair shape in dromedaries. The research confirms the KRT71 gene's role in hair structure and suggests the need for large-scale GWAS to identify other responsible genes, as well as testing the phenotyping protocol on a larger camel population.

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Research cited in this study

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Sequencing KRT71 as a Candidate Gene for Hair Shape Variation in Dromedary Camels

Research cited in this study

research Development of Woolly Hair and Hairlessness in a CRISPR-Engineered Mutant Mouse Model with KRT71 Mutations

research A KRT71 Loss-of-Function Variant Results in Inner Root Sheath Dysplasia and Recessive Congenital Hypotrichosis of Hereford Cattle

research Tracing Selection Signatures in the Pig Genome Provides Evidence for Selective Pressures on a Unique Curly Hair Phenotype in Mangalitza

research An Epistatic Effect of KRT25 on SP6 Is Involved in Curly Coat in Horses

research Types I and II Keratin Intermediate Filaments

research A Homozygous Missense Variant in Type I Keratin KRT25 Causes Autosomal Recessive Woolly Hair

research A Splice Variant in KRT71 Is Associated with Curly Coat Phenotype of Selkirk Rex Cats

research A Missense Mutation Within the Helix Initiation Motif of the Keratin K71 Gene Underlies Autosomal Dominant Woolly Hair/Hypotrichosis

research Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families

research The Naked Truth: Sphynx and Devon Rex Cat Breed Mutations in KRT71

research Autosomal-Dominant Woolly Hair Resulting from Disruption of Keratin 74 (KRT74), a Potential Determinant of Human Hair Texture

research Identification of the Rat Rex Mutation as a 7-bp Deletion at Splicing Acceptor Site of the Krt71 Gene

research Human Hair Keratin Network And Curvature

research Morphologic and molecular characterization of two novel Krt71 (Krt2-6g) mutations: Krt71 rco12 and Krt71 rco13

research K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) Represent the Type I Inner Root Sheath Keratins of the Human Hair Follicle

research A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type

research A missense mutation in the type II hair keratin hHb3 is associated with monilethrix

research A Small Deletion Hotspot in the Type II Keratin GenemK6irs1/Krt2-6gon Mouse Chromosome 15, a Candidate for Causing the Wavy Hair of the Caracul (Ca) Mutation

research Alopecia in a Novel Mouse Model RCO3 Is Caused by mK6irs1 Deficiency

research Hair Shape of Curly Hair

research A Novel Epithelial Keratin, hK6irs1, Is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells of the Human Hair Follicle

research A Novel Type II Cytokeratin, mK6irs, is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath

research Cyclic hair-loss and regrowth in transgenic mice overexpressing an intermediate filament gene.

research The Proteins of Hair and Other Hard α-Keratins

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