Development of Woolly Hair and Hairlessness in a CRISPR-Engineered Mutant Mouse Model with KRT71 Mutations

July 2023 in “ Cells ”

Tao Zhang, Hong Yao, Hejun Wang, Tingting Sui

CRISPR/Cas9 Krt71 Hypotrichosis simplex woolly hair hair follicle development hair shedding curly hair CRISPR KRT71 gene hair loss hair growth

Studysummary In this study, researchers created a mouse model using CRISPR/Cas9 technology to investigate hypotrichosis simplex and woolly hair, finding that Krt71-knockout mice exhibited curly hair and developed complete hair shedding without immune deficiencies, mimicking conditions seen in humans and potentially aiding future hair disorder research.

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research Bi-Allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause Autosomal-Recessive Hypotrichosis Simplex

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78 citations , May 2012 in “Journal of Investigative Dermatology”

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This review discusses major advances in understanding inherited hair diseases through genetic research and reports no new clinical results; the authors emphasize the potential for new preventive and therapeutic tools.

research The Naked Truth: Sphynx and Devon Rex Cat Breed Mutations in KRT71

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In this study, specific genetic polymorphisms in the KRT71 gene were associated with hairless and curly phenotypes in Sphynx and Devon Rex cats.

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research Identification of the Rat Rex Mutation as a 7-Bp Deletion at Splicing Acceptor Site of the Krt71 Gene

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This study identified a mutation in the keratin 71 gene that causes curly hair in certain rats, advancing our understanding of hair formation.

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This review summarizes the cell type distribution and functional significance of human keratins, emphasizing their roles in tumor diagnosis and potential clinical applications, and reports no new clinical findings.

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research Human Hair Growth Deficiency Is Linked to a Genetic Defect in the Phospholipase Gene LIPH

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research Disorders of the Hair and Scalp in Childhood

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